尼莫地平治疗高血压基底节区脑出血的临床疗效研究

目的 探讨尼莫地平治疗高血压基底节区脑出血的临床疗效.方法 80例高血压基底节区脑出血（出血量均小于30ml,均采用保守治疗）患者随机分为对照组（40例）和实验组（40例）,对照组给予传统疗法,实验组在此基础上加用尼莫地平（10mg/d＋ 500ml生理盐水）静脉滴注,观察两组患者血肿体积、水肿带面积、神经功能改善情况,并进行疗效评价.结果 治疗后,实验组有效率为92.5％,对照组有效率为65％,两组患者血肿量与水肿面积较治疗前比较均有改善（P＜0.05）,实验组疗效改善优于对照组（P＜0.05）.实验组神经功能评分与对照组比较差异有统计学意义（P＜0.05）.两组临床疗效比较,实验组优于对照组,差异有统计学意义（P＜0.05）.结论 尼莫地平能够减少血肿量和水肿带的面积,降低脑出血患者发生神经功能缺损和残疾.

Clinical effects of nimodipine in treatment of hypertensive basal ganglia hemorrhage

Objective To study the clinical effective of nimodipine in treatment of hypertensive basal ganglia hemorrhage patients. Methods Eighty patients with hypertensive basal ganglia hemorrhage were randomly divided into control group （40 cases） and treatment group （40 cases）, The control group was received conventional with intravenous drip, while the treat- ment group was treated with additionally intravenous drip of Nimodipine （10mg/d ＋500ml normal saline）. Conditions of hemato- ma volume, edema belt area and improvement of nerve functions of both groups were observed, and efficacies were assessed. Results After treatment, The total effective rate of treatment group （92. 5% ） were both higher than those of the routine group （65%, P 〈0. 05 ）. The volume of hematoma, area of edema belt and improvement of nerve functions in treatment group were all better than those of the control group （P 〈 0. 05 ）. Conclusion Nimodipine can significantly reduce the hematoma volume and the volume of edema and decrease the rate of neurologic impairment and disability occurrence.