进口10%过氧化苯甲酰乳膏(欧可喜)与国产5%过氧化苯甲酰凝胶治疗寻常痤疮临床疗效比较

研究进口10%过氧化苯甲酰乳膏治疗寻常痤疮的疗效和安全性,以国产5%过氧化苯甲酰凝胶作阳性对照,进行了随机对照平行试验.两药分别外用患处,每日2次,连续6周.结果:10%过氧化苯甲酰与5%过氧化苯甲酰比较治疗寻常痤疮的治愈率和有效率分别为30.2%,85.7%和14%,62.8% (P〈0.05).两药的药物不良反应发生率分别为17.2%和33.0%( P>0.05).结果提示进口10%过氧化苯甲酰治疗寻常痤疮、的疗效和安全性优于国产5%过氧化苯甲酰,也是一种安全有效治疗痤疮的外用药.

A Comparison of 10%Benzoyl Peroxide Cream and 5%Benzoyl Peroxide Gel in the Treatment of Acne Vulgaris

To evaluate the efficacy and safety of10% benzoyl peroxide cream in the treatment of acne vulgaris, a randomized, effectivecontrolled clinical trial was performed. 63 patients were given 10% benzoyl peroxide cream(imported) and the other 43 patients were given 5% benzoyl peroxide gel (domesticproduct). Both drugs were used on the surface of the skin 2 times a day for 6 weeks. Theresults showed that the curative rates and total effective rates were 30.2%, 85.7% and14%, 62.8% in two groups respectively. The effective rates were much higher for 10%benzoyl peroxide cream than 5% benzoyl peroxide gel (P<0.05) The adverse reactions toboth drugs were 17.2%, 33.0% respectively.