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Absence of Pneumocystis dihydropteroate synthase mutants in Brittany,France
Authors:Solè  ne Le Gal,Florence Robert-Gangneux,Maë  la Perrot,Amé  lie Rouillé  ,Michè  le Virmaux,Cé  line Damiani,Anne Totet,Jean-Pierre Gangneux,Gilles Nevez
Affiliation:1. University of Brest, LUBEM EA 3882, SFR 148, Brest, France;2. Laboratory of Parasitology and Mycology, Brest University Hospital, Brest, France;3. University of Rennes 1, INSERM U1085, Rennes, France;4. Laboratory of Parasitology and Mycology, Rennes University Hospital, Rennes, France;5. Department of Biochemistry and Pharmacology, Brest University Hospital, Brest, France;6. University of Picardy-Jules Verne, EA 4285 UMI INERIS 01, Amiens, France;g Department of Parasitology and Mycology, Amiens University Hospital, Amiens, France
Abstract:
Archival Pneumocystis jirovecii specimens from 84 patients monitored at Rennes University Hospital (Rennes, France) were assayed at the dihydropteroate synthase (DHPS) locus. No patient was infected with mutants. The results provide additional data showing that P. jirovecii infections involving DHPS mutants do not represent a public health issue in Brittany, western France.
Keywords:Pneumocystis jirovecii   DHPS   Mutants
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