米非司酮改善子宫内膜异位症临床症状的探讨

目的 探讨米非司酮治疗子宫内膜异位症的临床效果。方法 将确诊为子宫内膜异位症的病人36例进行治疗,口服米非司酮12.5mg,每日1次,晚餐后服,连服3个月。于治疗前后用B超监测子宫体积,内膜异位囊肿体积及检测血肝功能、促卵泡素、黄体生成素、泌乳素、雌激素、孕激素、雄激素指标。结果 病人在治疗期间均出现闭经、痛经症状消失、囊肿无增大且有缩小(P>0.05),性激素指标无明显改变。结论 米非司酮治疗子宫内膜异位症有一定效果,副作用小,12.5mg/d剂量是一种值得推广的保守治疗方法。

Exploration of improvement of clinical symptoms of endometriosis with mifepristone

Objective To explore the clinical effect of mifepristone in treating endometriosis. Methods Thirty-six cases of endometriosis were treated with mifepristone orally(12. 5 mg/d after supper everyday) for 3 monthes. Before and after treatment,the size of uterus and the cyst of endometriosis were measured and the levels of liver function, follicle stimulating hormone (FSH), luteining hormone, lactogen, estrogen, pro-gestin, androgen were detected. Results During treatment the symptoms of amenia and menalgia disappeared, the size of cysts reduced (P > 0. 05), while the indexes of sexual hormones changed little. Conclusion Mifepriston if effective to treat endometriosis with little side effect. The dosage of 12.5 mg/d is worth recommending for conservative treatment.