硫酸钙填充固定治疗胫骨平台塌陷性骨折的生物力学研究

目的 对比注射型半水硫酸钙填充植骨固定与单纯固定胫骨平台骨折的生物力学差异.方法 建立兔骨质疏松胫骨平台塌陷骨折模型,用硫酸钙填充植骨,克氏针固定,定期取材进行一般观察、大体X线、骨密度(BMD)分析、非脱钙切片检查、力学承载试验.结果 普通X线观察提示骨折区填充的硫酸钙逐渐降解吸收,被新生的骨组织替代.硫酸钙填充后1、2、3、4、6、8、12周骨折处样本BMD、轴向载荷承载能力明显高于对照组,差异有统计学意义(P＜0.01).结论 骨质疏松兔胫骨平台骨折填充硫酸钙早期能增加骨密度,提高轴向载荷承载能力.

Study on the biomechanics calcium sulfate bone cement to filling fixation in the treatment of tibial plateau collapse fracture

Objective To compare the biomechanical differences between injectable calcium sulfate hemihy- drate to fill the bone graft fixed and a simple fixed tibial plateau fractures. Methods Create a rabbit osteoporosis tibial plateau collapse fracture model ,filled with calcium sulfate bone graft and Kirschner wire fixation on a regular basis based on general observation, the general X-ray, bone mineral density （BMD） analysis, non-decalcified biopsy, mechanical loading experiment. Results Ordinary X-ray observations suggested that the fracture zone filled with calcium sulfate gradually degraded and absorbed by new bone tissue replacement. The 1,2,3,4,6,8,12 weeks after the filling of the bone cement treatment group rabbit calcium sulfate bone cement sample of the BMD of the fracture, the axial load carrying capacity was significantly higher than the blank control group, the difference was statistically significant （ P 〈 0. 01 ）. Conclusion Osteoporosis rabbit tibial plateau fracture filling calcium sulfate bone cement early can increase bone density, improve the axial load carrying capacity.