Lipid markers, coronary score and coronary artery disease of stable angina pectoris type

In 120 middle aged male patients with stable angina pectoris and coronarographically documented CAD all examined serum lipid markers differed significantly in comparison with 30 male subjects with vertebro-cardial syndrome and negative coronaro-angiogram (p less than 0.001). The low mean overall coronary score values (4.017 +/- 2.376) reflect the low extent of the coronary atherosclerosis. The coronary score values were significantly positively correlated to the serum levels of cholesterol, triglyceride, LDL-cholesterol, VLDL-cholesterol and negatively correlated to the serum concentration of HDL-cholesterol and HDL-cholesterol/total cholesterol ratios in all examined subjects (CAD and n-CAD groups) (p less than 0.001). In contrast, no significant correlation between coronary score and the examined lipid markers was exhibited in the CAD group of patients when comparing subjects with low and middle coronary score values. According to our results the ratio HDL-cholesterol/total cholesterol represents the best single indicator of the presence and also discriminator of the severity of the coronary athero-sclerosis in the patients with stable angina pectoris.