DDR 2基因突变与肺癌发生发展的相关性研究

【目的】探讨DDR2基因突变与肺癌发生的相关性，为肺癌的靶向治疗提供理论依据。【方法】选取上海交通大学附属胸科医院2010年5月至2012年5月确诊的200例肺癌患者及同期100例正常肺组织标本，分别纳入观察组及对照组，分析两组DDR2基因测序结果差异，并探讨基因突变与肺癌发生的相关性。【结果】观察组DDR2基因突变率为23．0％（46/200），对照组突变率为1．0％（1/100），观察组突变率显著高于对照组，且两组相比较差异有显著性（P ＜0．05）；肺鳞癌 DDR2基因突变率为51．4％（17/39），显著高于腺癌、鳞腺癌等其他病理分型，且差异均有显著性（P ＜0．05）；DDR2基因突变率与肿瘤分期无相关性（P ＞0．05）。【结论】DDR2基因突变是肺鳞癌发生的关键因素，但对肺癌的进展结果无明显影响。

Study on the Relationship Between DDR2 Gene Mutation and the Occurrence and Development of Lung Cancer

Objective]To explore the correlation between DDR2 gene mutation and the occurrence of lung cancer in order to provide the theoretical basis for the targeted therapy of lung cancer.Methods]Totally 200 patients with lung cancer and concurrent 100 cases of normal lung tissue samples in affiliated chest hospital of Shanghai Jiaotong university from May 2010 to May 2012 were selected and enrolled in observation group and control group,respectively.The difference in DDR2 gene sequencing results between two groups was ana-lyzed.The correlation between above indicators and the occurrence of lung cancer was discussed.Results]DDR2 gene mutation rate in observation group and control group was 23.0%（46/200）and 1.0%（1/100）,re-spectively.The mutation rate in observation group was markedly higher than that in control group,and there was significant difference between two groups（P 0.05）.Conclusion]DDR2 gene mutation is the key factor in the occurrence of lung squamous cell carcinoma,but has no obvious effect on the development of lung cancer.