An impending crisis in the provision of histopathology expertise for mouse functional genomics |
| |
| Authors: | MV Warren ML Studley P Dubus L Fiette B Rozell L Quintanilla‐Martinez M Raspa M Breuer J‐Y Song H Gates SDM Brown PN Schofield |
| |
| Affiliation: | 1. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK;2. University of Cambridge, Department of Histopathology, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK;3. Medical Research Council, Mammalian Genetics Unit, Harwell, Oxfordshire OX11 0RD, UK;4. Université de Bordeaux, Department of Experimental Histopathology, 146 Rue Léo Saignat, 33076 Bordeaux Cedex, France;5. Institut Pasteur, URE Histotechnologie et Pathologie, 25 Rue du Docteur Roux, 75724 Paris Cedex 15, France;6. Clinical Research Centre, Department of Laboratory Medicine, Karolinska Institutet, F46, Karolinska University Hospital, Huddinge, Stockholm, Sweden;7. Helmholtz Centre Munich, Research Centre for Environmental Health (GmbH), Institut für Pathologie, Ingolstaedter Landstrasse 1, 85764 Oberschleissheim, Germany;8. Consiglio Nazionale delle Ricerche, Istituto di Biologia Cellulare, European Mouse Mutant Archive, Campus A, Buzzati‐Traverso, Viale E. Ramarini 32, I‐00016 Monterotondo Scalo, Roma;9. The Netherlands Cancer Institute, Plesmanlaan 121, NL 1066 CX Amsterdam, The Netherlands;10. University of Cambridge, Department of Physiology, Development and Neuroscience, Downing Street, Cambridge CB2 3DY, UK |
| |
| Abstract: | ![]()
The generation of new mouse models of human disease is accelerating rapidly, due to the completion of whole‐genome sequencing efforts and technological advances in the manipulation of the mouse genome. We sought to investigate manpower issues in the provision of histopathology expertise for mouse functional genomics and compared this to the perceived demand from principal investigators (PIs). Through the European Commission (EC)‐funded PRIME pathology training initiative, two questionnaires were devised to collect information from pathologists and EC‐funded PIs on the current provision of mouse histopathology expertise in Europe and the demands for this service. We find that pathological analysis is being performed almost exclusively by professionally qualified pathologists, generally employed in clinical diagnostic posts, where the work is undertaken as collaboration outside of their contractual commitments but without previous training in veterinary or comparative pathology. The results indicate that there is a lack of both trainees and provision of specialist training in this field. Unsurprisingly, the availability of diagnostic expertise and advice falls far short of the number of genetically engineered mice (GEM) being generated for analysis. We analyse these results with reference to previous studies and discuss solutions for the future recruitment, training and funding for pathologists in mouse functional genomics in Europe. Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. |
| |
| Keywords: | pathology manpower questionnaire survey training recruitment mouse functional genomics phenotyping PRIME European Commission funding |
|
|
