Reversible posterior leuko‐encephalopathy in children with sickle cell disease |
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| Authors: | Zarir Khademian MD PhD Barbara Speller‐Brown PNP Seyed‐Medhi Nouraie MD PhD Caterina P. Minniti MD |
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| Affiliation: | 1. Department of Radiology, George Washington University, Children's National Medical Center, Washington, District of Columbia;2. Assistant Professor, George Washington University, Washington, DC.;3. Children's National Medical Center, Center for Cancer and Blood Disorders, Washington, District of Columbia;4. Center for Sickle Cell Disease, Howard University, Washington, District of Columbia;5. National Institutes of Health, NHLBI, Pulmonary and Vascular Medicine Branch, Bethesda, Maryland |
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| Abstract: | ![]()
Children with sickle cell disease (SCD) have high risk of neurologic morbidity and mortality, such as strokes, silent infarcts and TIA's. A retrospective review of magnetic resonance imaging and magnetic resonance angiography identified eight children with radiological and clinical characteristics of reversible posterior encephalopathy (RPLS). These patients had no evidence of previous cerebral infarcts or vasculopathy. Three have died during the 5‐year follow up; one developed a stroke and one a conditional TCD. RPLS needs to be considered in the differential diagnosis of children with SCD that present with acute neurological changes, especially if they are already been hospitalized. Pediatr Blood Cancer 2009;52:373–375. © 2008 Wiley‐Liss, Inc. |
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| Keywords: | hemoglobinopathies neurology and sickle cell sickle cell disease |
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