新疆汉族与维吾尔族心房颤动患者钠通道基因多态性与心房颤动易感性的相关性研究

目的 探究新疆汉族与维吾尔族心房颤动(房颤)患者钠通道基因的多态性与房颤易感性的相关性.方法 选取2016年6月至2018年6月在新疆医科大学第一附属医院诊断及治疗的汉族及维吾尔族房颤患者各100例,纳入房颤组;选择同时期非房颤的汉族及维吾尔族健康体检者各100例,纳入对照组.比较两组患者一般资料,包括:性别、年龄、血压、血脂、病史等情况,并进行钠离子通道(SCN5A)H558R位点基因多态性检测,使用多因素Logistic回归模型分析房颤的危险因素.结果 汉族及维吾尔族患者房颤组和非房颤组间年龄、总胆固醇和低密度脂蛋白胆固醇水平(LDL-C)的差异均具有统计学意义(P<0.05);SCN5A H558R位点基因符合Hardy-Weinberg平衡,汉族及维吾尔族房颤患者G等位基因频率均显著高于非房颤组,且基因型频率也与非房颤患者具有显著差异;多因素Logistic回归显示,汉族患者显性模型中(AG+GG)基因型(OR=2.72,P=0.012),共显性模型中AG基因型(OR=2.77,P=0.014)是房颤发生的独立危险因素;维吾尔族患者显性模型中(AG+GG)基因型(OR=2.37,P=0.012),共显性模型中AG基因型(OR=2.65,P=0.006)是房颤发生的独立危险因素;入组总患者显性模型中(AG+GG)基因型(OR=2.19,P=0.001),共显性模型中AG基因型(OR=2.20,P=0.001)是房颤发生的独立危险因素.结论 新疆汉族与维吾尔族房颤患者钠通道基因多态性与房颤均存在显著相关性,值得进一步深入研究.

The relationship between the polymorphism of sodium channel gene and the susceptibility of atrial fibrillation in Xinjiang Han and Uygur

Objective To explore the relationship between the polymorphism of sodium channel gene and the susceptibility of atrial fibrillation in Xinjiang Han and Uygur.Methods From June 2016 to June 2018,A total of 100 patients with atrial fibrillation of Han and Uygur nationalities diagnosed and treated in the First Affiliated Hospital of Xinjiang Medical University were enrolled in the atrial fibrillation group.A total of 100 non-atrial fibrillation Han and Uygur health examinees were enrolled in the control group.The general data of the two groups were compared,including sex,age,blood pressure,blood lipid and history.The polymorphism of H558R locus in sodium channel(SCN5A)was detected.Multivariate Logistic regression model was used to analyze the risk factors of atrial fibrillation.Results There were significant differences in age,total cholesterol and low-density lipoprotein cholesterol(LDL-C)between atrial fibrillation group and non-atrial fibrillation group(P<0.05).The gene of SCN5A H558R locus conformed to Hardy-Weinberg equilibrium.The G allele frequencies of patients with atrial fibrillation in Han and Uygur nationalities were both significantly higher than those in non-atrial fibrillation group and the genotype frequencies were also significantly different from those in non-atrial fibrillation group.Multivariate Logistic regression showed that in the dominant model of Han population the dominant genotype(0R=2.72,P=0.012)and the co-dominant genotype(()R=2.17,P=0.014)were independent risk factors for atrial fibrillation;in the dominant model of Uygur population(()R=2.37,P=0.012),the AG genotype(OR=2.65,P=0.006)was an independent risk factor for atrial fibrillation.In the total population dominant model(AG+GG)genotype(O/?=2.19,P=0.001),AG genotype(()R=2.2Q,P=0.001)in the co-dominance model was an independent risk factor for atrial fibrillation.Conclusion There is a significant correlation between sodium channel gene polymorphism and AF in Xinjiang both Han and Uygur patients,which is worth further study.