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A novel analgesic pyrazine derivative from the leaves of Croton tiglium L. |
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| Authors: | Xin-An Wu Yi-Min Zhao Neng-Jiang Yu |
| Affiliation: | a Laboratory of Phytochemistry, Beijing Institute of Pharmacology and Toxicology, Beijing, China |
| Abstract: | A novel analgesic pyrazine derivative, named crotonine, was isolated from the leaves of Croton tiglium L. The structure was elucidated as 2-(furan-2-yl)-5-(2,3,4-trihydroxy-butyl)-1,4-diazine by spectroscopic analysis. Crotonine inhibited remarkably the acetic acid-induced writhing in mice. |
| Keywords: | Croton tiglium L Euphoriaceae 2-(Furan-2-yl)-5-(2 3 4-trihydroxy-butyl)-1 4-diazine Crotonine analgesic effects |
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