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| 神经生长因子对脊髓前角运动神经元的保护作用 | |
| 引用本文： | 庞清江 罗永湘. 神经生长因子对脊髓前角运动神经元的保护作用[J]. 中华手外科杂志, 1997, 13(1): 19-21 |
| 作者姓名： | 庞清江 罗永湘 |
| 作者单位： | 山东滨州医学院附属医院骨科，同济医科大学附属同济医院骨科 |
| 摘 要： | 目的：证实神经生长因子（ｎｅｒｖｅｇｒｏｗｔｈｆａｃｔｏｒ，ＮＧＦ）对脊髓前角运动神经元有保护作用。方法：切断ＳＤ大鼠一侧坐骨神经，借助单盲端硅胶管系统在神经损伤局部给予ＮＧＦ。术后行酶组织化学检测。结果：坐骨神经切断可致腰段脊髓前角运动神经元明显损害，其表现为神经元乙酰胆碱脂酶（ａｃｅｔｙｌ－ｃｈｏｌｉｎｅｓｔｅｒａｓｅ，ＡｃｈＥ）活性降低和酸性磷酸酶（ａｃｉｄｐｈｏｓｐｈａｔａｓｅ，ＡＣＰ）活性升高，应用ＮＧＦ可显著改善上述酶学变化。结论：ＮＧＦ对受伤的脊髓前角运动神经元有保护作用 |
| 关 键 词： | 神经生长因子 坐骨神经 脊髓 运动神经元 创伤和损伤 |
Protective effect of nerve growth factor on spinal motor neurons |
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| Pang Qingjiang,Luo Yongxiang,Fang Qingmin. Protective effect of nerve growth factor on spinal motor neurons[J]. Chinses Journal of Hand Surgery, 1997, 13(1): 19-21 | |
| Authors: | Pang Qingjiang Luo Yongxiang Fang Qingmin |
| Affiliation: | Pang Qingjiang,Luo Yongxiang,Fang Qingmin. Department of Orthopedics,Affiliated Hospital,Binzhou Medical College,Shandong 256603 |
| Abstract: | Objective:To investigate the protective effect of nerve growth factor(NGF) on spinal motor neurons. Methods: The sciatic nerve was sectioned unilaterally and NGF was supplied locally to the proximal nerve stump using a single blind silicone tube. Enzyme histochemical technique was conducted after operation. Results: Sciatic nerve section did injure the spinal motor neurons. There was a decrease in acetylcholinesterase(ACHE) activity and an increase in acid phosphatase(ACP) activity. Application of NGF could significantly improve the above mentioned enzymatic activity changes. Conclusions: NGF plays a role in protecting the spinal motor neuron against injury. |
| Keywords: | Nerve growth factor Sciatic nerve Spinal Motor neuron Wounds and injuries |
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