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Protective Effect of Shengmai Injection on Rats with Contrast Medium-Associated Acute Renal Failure
引用本文:段绍斌,罗季安,刘瑞洪,徐锡萍. Protective Effect of Shengmai Injection on Rats with Contrast Medium-Associated Acute Renal Failure[J]. 中国结合医学杂志, 1998, 0(4)
作者姓名:段绍斌  罗季安  刘瑞洪  徐锡萍
摘    要:ThisworkwassupportedbythegrantfromtheHealthAdministrationofHunanProvinceContrastmedium--associatednephropathy(CAN)maybedefinedasartacuterenaldysfunctioniflducedbyradiographiccontrastmedia.Itwasreportedtoberesponsiblefor10%ofallcasesofhospital--acquiredacuterenalfailure,andthepre--existingrenalimpairmentisthemostprevalentdangerousfacto.(l).ThepathogenesisofCANmayberelatedwithrenalischemiaanddirectnephrotoxicityofthecontrastmedia.EffectivepreventionofCANislackingsofar.StudiesprovedthatShen…


Protective Effect of Shengmai Injection on Rats with Contrast Medium-Associated Acute Renal Failure
Duan Shaobin , Luo Ji'an , Liu Ruihong The Second Affiliated Hospital of Hunan Medical University,Changsha. Protective Effect of Shengmai Injection on Rats with Contrast Medium-Associated Acute Renal Failure[J]. Chinese journal of integrative medicine, 1998, 0(4)
Authors:Duan Shaobin    Luo Ji'an    Liu Ruihong The Second Affiliated Hospital of Hunan Medical University  Changsha
Abstract:Objective: Radiographic contrast media can induce renal failure and it may serve as an experimental model of acute renal failure (ARF). The study was aimed to determine the protective effect of Shengmai Injection (SMI) on contrast medium-associated ARF in Sprague-Dawley (SD) rats. Methods: Twenty healthy SD rats of both sex were randomly divided into two groups, Group A (control group) treated with glycerin 0.9 % saline meglucamine diatrizoate, and group B (preventive group) with glycerin SMI meglucamine diatrizoate. Results: In Group B, the levels of blood urea nitrogen, serum creatinine, renal phospholipase A2 (PLA2) and calcium were all significantly lower than those in Group A, P < 0. 01. The results indicated the renal injury induced by meglucamine diatrizoate was alleviated by SMI. Conclusion: SMI could prevent renal tissue from contrast media induced nephropathy in SD rats. The effect may partially owe to its preventing intracellular calcium accumulation, inhibiting PLA2 activity and dilating renal vessels.
Keywords:nephrotoxicity   contrast media   Shengmai Injection   renal failure   meglucamine diatrizoate
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