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Oral delivery of Hyperimmune bovine serum antibodies against CS6-expressing enterotoxigenic Escherichia coli as a prophylactic against diarrhea |
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| Authors: | KR Talaat AL Bourgeois TK Lee CA Duplessis M Maciel Jr. |
| Affiliation: | 1. Bloomberg School of Public Health, Johns Hopkins University , Baltimore, MD, USA !["ORCID]({"type":"image","src":"/templates/jsp/images/orcid.png"} "\"ORCID") https://orcid.org/0000-0002-4899-6260;2. Bloomberg School of Public Health, Johns Hopkins University , Baltimore, MD, USA;3. Enteric Diseases Department, Naval Medical Research Center , Silver Spring, MD, USA;4. The Henry M. Jackson Foundation , Bethesda, MD, USA https://orcid.org/0000-0003-4877-9458 |
| Abstract: | ABSTRACT Background. Oral administration of bovine antibodies active against enterotoxigenic Escherichia coli (ETEC) have demonstrated safety and efficacy against diarrhea in human challenge trials. The efficacy of bovine serum immunoglobulins (BSIgG) against recombinant colonization factor CS6 or whole cell ETEC strain B7A was assessed against challenge with the CS6-expressing B7A. |
| Keywords: | Enterotoxigenic Escherichia coli controlled human infection model diarrhea passive prophylaxis |