| 血栓调节蛋白及纤溶酶原激活物抑制剂-1在糖尿病视网膜病变中的作用 |
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| 引用本文： | 王鲁伃,刘素筠. 血栓调节蛋白及纤溶酶原激活物抑制剂-1在糖尿病视网膜病变中的作用[J]. 医学综述, 2006, 12(10): 593-595 |
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| 作者姓名： | 王鲁伃 刘素筠 |
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| 作者单位： | 山西医科大学第二临床医学院内分泌科,太原,030001 |
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| 摘 要： | 糖尿病视网膜病变(DR)是糖尿病最严重的并发症之一。视网膜微循环内微血管病变伴血栓形成及新生血管形成在DR的发生发展中起重要的作用。血浆血栓调节蛋白(TM)和纤溶酶原激活物抑制剂(PAI-1)均可反映血管内皮的功能,抑制纤溶活性,促进凝血,参与血管生成,增加视网膜血管通透性等,最终导致DR。所以研究TM和PAI-1在DR中的作用机制对DR及时治疗和预防具有重要意义。
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| 关 键 词： | 糖尿病视网膜病变 血栓调节蛋白 纤溶酶原激活物抑制剂 |
| 文章编号： | 1006-2084（2006）10-0593-03 |
| 收稿时间： | 2005-10-29 |
| 修稿时间： | 2006-05-05 |
The Role of TM and PAI-1 in Diabetic Retinopathy |
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| WANG Lu-yu,LIU Su-jun. The Role of TM and PAI-1 in Diabetic Retinopathy[J]. Medical Recapitulate, 2006, 12(10): 593-595 |
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| Authors: | WANG Lu-yu LIU Su-jun |
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| Affiliation: | The Department of Endocrinolo- gy, the Second Clinical Medical College of Shanxi Medical University, Taiyuan 030001 |
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| Abstract: | Diabetic retinopathy(DR) was one of the most severe microvascular complications of diabetes mellitus(DM).Microangiopathy companyed by thrombopoiesis and neovascularization of retina were very important in the development of DR.Both plasma thrombomodulin(TM) and plasminogen activator inhibitor-1(PAI-1) can reflect the function of endothelial cell,inhibit fibrinolysis,promote coagulation,participate in angiogenesis,increase retinal vascular permeability,which then resulted in the occurrence of DR at last.So we studied the mechanism of TM and PAI-1 in DR,which was important for the therapy and prevention of DR. |
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| Keywords: | Diabetic retinopathy Thrombomodulin Plasminogen activator inhibitor-1 |
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