反复注射甘露醇致兔耳静脉组织炎的病理变化

目的探讨不同穿刺方法反复静脉注射甘露醇引起兔耳静脉及周围组织炎症的病理变化。方法12只新西兰兔按左右耳静脉随机分为单次穿刺组(A组)和留置套管针组(B组),每组12例,经耳静脉反复注射等量20%甘露醇,观察静脉炎发生率和耳静脉及周围组织的常规染色病理变化。结果两组兔耳静脉均发生程度不同的血管内聚集红细胞和周围组织炎性浸润,静脉炎严重程度与病理变化一致。两组静脉炎发生率具有显著性差异(P<0.05),B组大于A组。结论留置套管针组静脉炎发生率要高于单次静脉穿刺组,静脉炎表现程度与病理变化相吻合。

Pathological Inflammatory Changes of Periphery Veins and Tissues in Rabbits after Recurrent Transfusion with 20% Mannitol

Objective To observe the pathological inflammatory changes of periphery veins and around tissues in rabbits after recurrent transfusion with 20% mannitol.Methods 12 Zelanian rabbits were randomly divided into 2 groups,6 cases for each group.Group A of single injection,group B of intubations.Clinical manifestations of punctured veins and periphery tissues of rabbit's ears were observed.Pathological changes were studied by microscope in punctured veins and periphery tissues of rabbit's ears.Results There were significant differences in group A and B.Pathological changes such as stasis of red blood cells in vein,hypodermic hemorrhage,fibrous tissue hyperplasia,formation of thrombosis were observed in group B.There were significant different changes between group A and B(P<0.05).Conclusions The degrees of periphery vein and around tissue inflammation after different transfusion with intravenously 20% mannitol are different.It suggests that intravenous by deep vein intubations can avoid these damages.