芍药甘草汤治疗利培酮所致高催乳素的临床研究

目的：探讨芍药甘草汤治疗利培酮所致的高催乳素血症的临床应用价值及安全性。方法：回归性分析研究2011年1月-2012年3月在本院接受治疗的92例因服用利培酮导致高催乳素血症的精神病患者（催乳素水平≥1888.5μg/ml）,分析所有患者服用芍药甘草汤后利培酮血浆浓度及9-羟利培酮血浆浓度、催乳素、血药浓度、PANSS评定等指标。结果：与治疗前相比,患者在治疗后的血清泌乳素水平显著下降（P〈0.05）,但雌二醇、睾酮、孕酮浓度治疗前后的浓度、TESS评分和治疗后的利培酮血浆浓度及9-羟利培酮血浆浓度无显著差异。结论：芍药甘草汤治疗利培酮所致的高催乳素血症可快速改善月经不调、闭经、男性女性化等症状,提高患者服药依从性,且服药方便,疗效明显,价格低廉,安全可靠,值得临床推广应用。

Clinical Study on Shaoyao Gancao Decoction for Treating Risperidone-induced Hyperprolactinemia

Objective： To investigate the clinical application value shaoyao-gancao decoction in the treatment of hyperprolactinemia induced by risperidone and its safety.Method：92 psychiatric patients with hyperprolactinemia induced by risperidone from 2011 January to 2012 March in our hospital were analyzed resrospectively （ prolactin levels ~〉 1888.5 tr g/ml ）, analyzed the indices of plasma concentration of risperidone and 9-hydroxyrisprridone, prolactin, blood concentration, PANSS evaluation were observed in all patients.Result： Compared with before treatment, the serum prolactin level after treatment decreased significantly （P〈0.05）, but there were no differences in the estradiol, testosterone, progesterone concentrations, the TESS score before and after treatment and the plasma concentration of risperidone and 9-hydroxyrisprridone after treatment.Conclusion： Shaoyao-gancao decoction treatment of risperidone caused by high blood prolactin can rapidly improve the male feminine irregular menstruation, amenorrhea, Male female etc, enhance patient medication adherence, and taking convenient, obvious curative effect, low price, safe and reliable, worthy of clinical popularization and application.