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| Effects of Ligustrazine on the Contraction of Isolated Rabbit Corpus Cavernosum Strips | |
| 引用本文： | 肖恒军,刘继红,尹春萍,王涛,陈俊,樊龙昌,叶章群. Effects of Ligustrazine on the Contraction of Isolated Rabbit Corpus Cavernosum Strips[J]. 华中科技大学学报(医学英德文版), 2005, 25(5): 565-567. DOI: 10.1007/BF02896019 |
| 作者姓名： | 肖恒军 刘继红 尹春萍 王涛 陈俊 樊龙昌 叶章群 |
| 作者单位： | Department of Urology Tongji Hospital，Huazhong University of Science and Technology Wuhan 430030 China，Department of Urology Tongji Hospital，Huazhong University of Science and Technology Wuhan 430030 China，Department of Pharmacology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China，Department of Urology Tongji Hospital，Huazhong University of Science and Technology Wuhan 430030 China，Department of Urology Tongji Hospital，Huazhong University of Science and Technology Wuhan 430030 China，Department of Urology Tongji Hospital，Huazhong University of Science and Technology Wuhan 430030 China，Department of Urology Tongji Hospital，Huazhong University of Science and Technology Wuhan 430030 China |
| 摘 要： | Ligustrazine(tetramethylpyrazine,TMP)is avasoactiveingredient that has beenisolated and pu-rified fromLigusticum Chuanxiong Hort.(Um-belliferae)behind an ancient Chinese herbal reme-dy.It has been widely used for the treat ment of avariety of vascular diseases such as occlusive cere-bral arteriolar diseases,notable ischemic strokeand pul monary hypertension secondary to chronicobstructive pul monary disease(COPD)due to itsvasodilatory actions.Ligustrazine has previouslybeen shown to be eff… |
| 关 键 词： | 肌肉收缩 钙离子 家兔 动物实验 川弓嗪 |
| 收稿时间： | 2004-05-19 |
Effects of ligustrazine on the contraction of isolated rabbit corpus cavernosum strips |
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| Xiao Hengjun,Liu Jihong,Yin Chunping,Wang Tao,Chen Jun,Fan Longchang,Ye Zhangqun. Effects of ligustrazine on the contraction of isolated rabbit corpus cavernosum strips[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2005, 25(5): 565-567. DOI: 10.1007/BF02896019 | |
| Authors: | Xiao Hengjun Liu Jihong Yin Chunping Wang Tao Chen Jun Fan Longchang Ye Zhangqun |
| Affiliation: | 1. Department of Urology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630,China 2. Department of Urology, Tongji Hospital,Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 , China 3. Department of Pharmacology Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 , China |
| Abstract: | Summary To investigate the role of ligustrazine on relaxation of the isolated rabbit corpus cavernosum tissuein vitro, the effects of ligustrazine on the corpus cavernosum were observed by using experimental method of smooth muscle strips. Concentration-responses to phenylephine (PE) and KCl were recorded. The results showed that ligustrazine concentration-dependently depressed the contraction response of smooth muscle strips induced by PE. The maximum percentage relaxation of cavernosal strips by ligustrazine was 74.1%±6.2% (compared with control: 21.9%±5.6%P<0.01). Ligustrazine concentration-dependently reduced the amplitude of the contraction induced by cumulative doses of PE or KCl, shifted the cumulative concentration response curves of PE and KCl to the right and depressed their maximal responses. It was concluded that ligustrazine could significantly relax the cavernosal muscle contraction induced by PEin vitro. The results suggested that ligustrazine inhibited calcium ion influx. XIAO Hengjun, male, born in 1972, Doctor in Charge, M. D., Ph. D. |
| Keywords: | ligustrazine corpus cavernosum calcium channel concentration |
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