肿瘤标志物联合检测在肺癌诊断中的价值

目的 探讨肿瘤标记物CEA、CA-50、CA242、CA125、NSE在肺癌诊断中的价值。方法 应用时间分辨荧光免疫法测定45例肺癌、31例肺良性病变、28例经体检证明是健康人的血清肿瘤标记物水平。结果 肺癌患者五项血清肿瘤标记物浓度均高于肺良性病变及健康组（P〈0．01，P〈0．05）。敏感性分别是CEA42．4％（19／45），CA-50 40．4％（18／45），CA242 33．3％（15／45），CA12．5 28．9％（13/45）、NSE 26．7％（12／45），联合检测敏感性达到91．1％。结论 联合检测CEA、CA-50、CA242、CA12．5、NSE可以显著提高肺癌血清肿瘤标记物的敏感性和特异性，为肺癌诊断提供科学的方法和依据。

The diagnostic value of tumor''''s markers conjoined detection for lung cancer

Objective To search the diagnostic value of the conjoined detection method for tumor markers CEA,CA-50,CA242,CA125 and NSE for lung cancer.Methods Choose 45 cases of lung cancer,benign lung diseases 31 cases and 21 health persons as control group.Then apply time distinguish fluorescence immunity technique to determine the level of tumor markers in the blood serum.Results The concentrations of the five tumor markers in the cancer patients group are higher than that of the benign lung diseases group and the health control group(P<0.01 and P<0.05).The sensitivities are CEA 68.9%(31/45),CA-50 66.7%(30/45),CA242 55.6%(25/45),CA125 48.9%(22/45) and NSE 44.4%(20/45) respectively.However,the sensitivity of combing detection achieves 95.6%(43/45).Conclusion The conjoined detection of CEA,CA-50,CA242,CA125 and NSE promote distinctively the sensitivity and specificity for lung cancer patients,which will provide a scientific and reliable method for diagnosis of lung cancer.