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A phase 2, randomized dose-finding study of tapinarof (GSK2894512 cream) for the treatment of atopic dermatitis
Authors:Johnny Peppers  Amy S. Paller  Tomoko Maeda-Chubachi  Sterling Wu  Kevin Robbins  Kelly Gallagher  John E. Kraus
Affiliation:1. PRA Health Sciences, Raleigh, North Carolina;2. Feinberg School of Medicine, Northwestern University, Chicago, Illinois;3. Novan Inc, Morrisville, North Carolina;4. GlaxoSmithKline, Collegeville, Pennsylvania;5. ICON plc, Research Triangle Park, North Carolina
Abstract:
Keywords:atopic dermatitis  GSK2894512  tapinarof  therapeutic aryl hydrocarbon receptor modulating agent  AE  adverse event  AhR  aryl hydrocarbon receptor  BSA  body surface area  CI  confidence interval  EASI  Eczema Area and Severity Index  EASI75  75% or greater improvement in Eczema Area and Severity Index score  IGA  Investigator's Global Assessment  NRI  nonresponder imputation  NRS  numeric rating scale  TEAE  treatment-emergent adverse event
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