肠道微生物群在血栓形成及心脑血管疾病中的研究进展

心脑血管疾病作为临床常见病,具有高发病率、高致残率及高死亡率的特点。研究认为血小板黏附、活化及聚集引起的血管内血栓是导致心脑血管疾病发生的重要原因之一,因此,探索和明确有关血小板活化及血栓形成的因素是预防和控制心脑血管疾病的重要切入点。最近的研究显示肠道微生物群作为人体内最大最复杂的微生态系统参与到血小板功能的调控中。笔者对肠道微生物群参与血栓形成及作为血栓性疾病治疗手段的最新进展进行综述,从而为肠道微生物群为基础的治疗方案在心脑血管疾病中的临床应用提供新的思路和理论依据。

Research Progress of Gut Microbiota in the ThrombosisFormation and Cerebro-Cardiovascular Disease

Abstract:Cerebro-cardiovascular disease which is commonin clinical practice is featured by its high incidence,morbidity and mortality.So studies have shown that adhesion,activation and aggregation of the platelets and thrombosis induced by platelets are considered to play a critical role inthe pathogenesis of cerebro-cardiovascular disease,therefore,exploration andidentification of the factors involved in the platelet activation and thrombosis formation is an important incision for prevention and control of cerebro-cardiovascular disease.Recent studies have suggested that gut microbiota,as the most largest and complicated micro-ecosystem in human body,is participated in the platelet function regulation.Here,author reviewed the recent progress aboutthe role of gut microbiota in thrombosis formation and its therapeutic potential,and these data are believed to provide novel insight and theory basis for application of gut microbiota-base treatment regimen in the cerebro-cardiovasculardiseases.