2型糖尿病患者血清网膜素-1水平与肾损伤程度关系的研究

目的 探讨血清网膜素-1(serum omentin-1)水平与2型糖尿病(T2DM)肾病发病的关系。方法 将100例2型糖尿病肾病患者按糖尿病肾病(diabetic nephropathy,DN)诊断标准分为DM组(44例)与DN组(56例)。按照Mogenson分期将DN组分为DN早期(DN1)30例,DN晚期(DN2)26例。另择80例健康体检者作为正常对照组(NC)。同时检测糖化血红蛋白(HbA1c)、肌酐(Scr)、尿素氮(BUN)、β2微球蛋白(β2-MG)、胰岛素抵抗指数(HOMA-IR)和血清网膜素-1,进行相关的统计学分析。结果DM,DN和NC组HbA1c,Scr,BUN,β2-MG,HOMA-IR和血清网膜素-1指标差异均有统计学意义(F=6.078～16.231,均P<0.05)。其中DM组和NC组间除了HbA1c和HOMA-IR以外,其它检测指标相比差异均无统计学意义(t=1.421～2.637,均P>0.05),而DN组与NC组上述六项指标相比差异均有统计学意义(t=8.981～26.785,均P<0.05)。DN组和DM组间检测指标差异均有统计学意义(t=6.371～21.673,均P<0.05)。DN1组和DN2组间HbA1c,Scr,BUN和β2-MG差异均无统计学意义(t=0.981～1.389,均P>0.05)。而DN2组HOMA-IR水平明显比DN1组高,而血清网膜素-1水平明显比DN1组低,两组差异均有统计学意义(t=68.451～76.814,均P<0.01)。DN组HOMA-IR水平与血清网膜素-1指标呈显著负相关(r=-0.405,P<0.05)。结论 血清网膜素-1与胰岛素抵抗关系密切,血清网膜素-1可能是2型糖尿病患者肾脏损伤程度的靶标。

Study on the Relationship between Serum Omentin-1 Level andDegree of Kidney Injuryin Patient with Type 2 Diabetic Nephropathy

Abstract:Objective To explore the relationship between serum Omentin-1 level and degree of kidney in juryin patient with type 2 diabetic nephropathy.Methods 100 diabetic patients with suspected DN were devided into two groups:DM(44 cases)and DN(56 cases)group,andby Mogenson,DN group were devided into DN1(30 cases)and DN2(26 cases).In addition 80 healthy subjects were selected as control group.HbA1c,BUN,Scr,β2-MG,HOMA-IR and serum Omentin-1 leves were detected by thestandard method.Results There were obvious differences of HbA1c,BUN,Scr,β2-MG,HOMA-IR and Serum Omentin-1 levels among DN,DM and NC(F=6.078～16.231,all P<0.05).Apart of HbA1c and HOMA-IR,others were no differences between DM group and NC group(t=1.421～2.637,allP>0.05).There were significant differences of these indicators between DNand NC group(t=8.981～26.785,all P<0.05).DN group was higher significantly than these in DM group(t=6.371～21.673,all P<0.05),and HbA1c,BUN,Scr and β2-MG levels had no statistical difference between DN1 andDN2 group(t=0.981～1.389,all P>0.05).HOMA-IR level in DN2 was higher than that in DN1 group,and serum Omentin-1 declined(t=68.451～76.814,all P<0.01).There were negative correlation between HOMA-IR and serum Omentin-1 leves(r=-0.405,P<0.05).Conclusion Serum Omentin-1 was related to insulin resistance.Serum Omentin-1 in serummay be a role indicator for impairment of renal function for diagnosis of type 2diabetic nephropathy.