IL-17及其受体在多发性骨髓瘤中的表达及意义

目的分析多发性骨髓瘤(MM)患者血清白细胞介素-17(IL-17)表达及其受体(IL-17R)在骨髓瘤细胞表达,探讨其对多发性骨髓瘤的作用。方法采用ELISA法检测MM患者不同病程血清IL-17水平,对IL-17与MM预后及肿瘤负荷指标IL-6进行相关性分析;采用免疫组化法检测MM初治患者骨髓瘤细胞IL-17R表达。结果 IL-17在MM初治组、MM复发组及MM进展组呈高表达,随疾病稳定而下降,各期MM患者血清IL-17与同期IL-6呈正相关;MM初治患者骨髓瘤细胞IL-17R高表达。结论 MM患者IL-17水平明显增高,促进骨髓瘤细胞增殖。

Expression of Interleukin -17 and its receptor in multiple myeloma and its significance

【Objective】 To analysis the expression of peripheral serum IL-17 and the expression of IL-17R in myeloma cell and probe their relation to multiple myeloma pathogenesis.【Methods】 ELISA method was used to detect the expression of peripheral serum IL-17 in multiple myeloma patients at different times.To analysis IL-17 in multiple myeloma and their correlation with clinical tumor burden prognosis indices such as IL-6.Immunohistochemistry was used to detect expression of IL-17R in multiple myeloma patients with untreated.【Results】 The levels of IL-17 in multiple myeloma were significantly higher in untreated group,recurrence group and progress group than those in control group and plateau group,with the steady decline in disease.The serum levels of IL-17 in multiple myeloma at different times were positively correlated with that of the serum levels IL-6 in corresponding stage.IL-17R was highly expressed in myeloma cell in multiple myeloma patients with untreated.【Conclusion】 IL-17 were significantly increased,so as to promote the growth of myeloma cells in MM.