缺氧习服对冻伤大鼠血液流变性质的影响

为进一步探讨缺氧习服大鼠较未习服鼠冻伤的程度更为严重的原因。对平原（ＦＮ）、急性缺氧（ＦＡＨ）和缺氧习服（ＦＨＡＣ）大鼠冻伤前后血液流变性质的改变进行了观测。ＦＨＡＣ组大鼠在模拟的高原条件下锻炼４周后，与其余两组一起接受冷冻处理，造成双后足重度冻伤。在冻前及冻后不同时间，各组动物分别由心脏穿刺采血，测定各项流变学参数。结果表明，冻伤前ＦＨＡＣ组ＲＢＣ比积、全血粘度、ＫＢＣ聚集指数及硬度明显高于ＦＮ及ＦＡＨ组，变形指数明显低于二者（Ｐ＜０．０５）。冻伤后各组上述指标均明显改变，与冻前比较，冻后２４小时ＦＮ、ＦＡＨ及ＦＨＡＣ组全血粘度分别增加３５．９％、２９．０％、１６２．８％（Ｐ＜０．０１），ＲＢＣ聚集指数分别增加３１．６％、１１７．５％、１６６．３％（Ｐ＜０．０５）。提示缺氧习服和冷冻损伤均可引起大鼠血液流变性质明显恶化，而缺氧习服冻伤后血液流变性质恶化的程度更趋严重。这是造成缺氧习服大鼠冻伤程度更为严重的原因之一。

The influence of acclimation to hypoxia on hemorrheological behaviour in rats with frostblte

lt was found that cold injury in rats acclimated to hypoxia was more severe than that innonacclimated ones,In order to go into the cause further,the changes of hemorrheological behaviour ofrats pre-and post- frostbite in normoxia(FN),acute hypoxia(FAH)and hypoxic acclimation (FHAC)groups were observed. The rats in FHAC group were exposed to simulated high altitude for four weeks.Then the hind-feet of rats in all three groups were frozen to form severe frostbite.Blood samples usedfor the determination of hemorrheological parameters were withdrawn by cardiac puncture.The resultsindicated that before frostbite,RBC hematocrit,blood viscosity, index of RBC aggregation and RBChardness in rats of FHAC group were obviously higher and index of RBC deformation was lower thanthat in FN and FAH groups. In all groups, these parameters altered after frostbite as compared withthemselves before frostbite, At 24 h post-frostbite,the blood viscosity increased by 35.9%,29.0%,162.8%(P<0.05)and the index of RBC aggregation increased by 31.6%,117.5%and 166.3%(P<0.05) respectively in FN,FAH and FHAC group. It is suggested that the more severe change in hemor-rheological behaviour of rats acclimated to hypoxia may be one of the factors leading to more severedamage of frostbite tissue in rats acclimated to hypoxia.