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| 慢性乙肝患者HBV-DNA定量与肝脏病理及血清ALT关系的探讨 | |
| 引用本文： | 周文虹,陈书裕,费选文. 慢性乙肝患者HBV-DNA定量与肝脏病理及血清ALT关系的探讨[J]. 江西医学检验, 2011, 0(4): 369-370,372 |
| 作者姓名： | 周文虹 陈书裕 费选文 |
| 作者单位： | 广东省汕头市中心医院检验科; |
| 摘 要： | 目的研究慢性乙型肝炎（CHB）患者HBV-DNA复制水平及其与肝组织病理学、血清ALT水平的相关性。方法采用荧光定量聚合酶链反应（PCR）监测300例慢性乙型肝炎患者血清HBV-DNA含量及测定相关血清ALT水平,并对患者活体肝穿刺的病理标本进行组织炎症活动度分级（G）和纤维化程度分期（S）,结果利用统计软件统计分析。结果慢性乙肝患者血清HBV-DNA定量与炎症分级有明显相关性（P〈0.05）,但是与纤维化分期无明显相关性（P〉0.05）,而血清HBV-DNA定量（103～106）与血清ALT水平有较好一致性（P〈0.05）。结论血清HBV-DNA定量结合血清ALT在一定条件下可较好评价肝脏炎症活动程度,但对于评价肝脏纤维化分期有一定不足。 |
| 关 键 词： | 乙型肝炎 HBV-DNA ALT 肝组织病理 |
The relative study between serum quantitative HBV-DNA,ALT level and liver lesions in patients with chronic hepatitis B |
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| ZHOU Wenhong,CHEN Shuyu,FEI Xuanwen.Shantou Central Hospital,Guangdong Shantou ,China. The relative study between serum quantitative HBV-DNA,ALT level and liver lesions in patients with chronic hepatitis B[J]. Jiangxi Journal of Medical Laboratory Sciences, 2011, 0(4): 369-370,372 | |
| Authors: | ZHOU Wenhong CHEN Shuyu FEI Xuanwen.Shantou Central Hospital Guangdong Shantou China |
| Affiliation: | ZHOU Wenhong,CHEN Shuyu,FEI Xuanwen.Shantou Central Hospital,Guangdong Shantou 515031,China |
| Abstract: | Objective To investigate the correlation between quantitative HBV DNA,serum ALT level and liver lesions of chronic hepatitis B(CHB).Methods Serum HBV-DNA contents from 300 CHB patients were determined by fluorescence quantitative polymerase chain reaction and serum ALT detection by biochemical analyzer.The inflammatory activities and fiberization were graded and staged by liver histopathology.The results were analyzed with statistical software.Results There was a significant correlation between serum HBV-DN... |
| Keywords: | Hepatitis B HBV-DNA ALT Liver histopathology |
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