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| 良、恶性前列腺组织中SOD、CAT和MDA含量的变化 | |
| 引用本文： | 刘庆勇,党建功,南勋义,贺大林,王明珠,陈兴发,王继英. 良、恶性前列腺组织中SOD、CAT和MDA含量的变化[J]. 现代泌尿外科杂志, 2001, 6(1): 22-24 |
| 作者姓名： | 刘庆勇 党建功 南勋义 贺大林 王明珠 陈兴发 王继英 |
| 作者单位： | 1. 710061,西安交通大学第一医院泌尿外科 2. 西安市第一人民医院泌尿外科 |
| 摘 要： | 目的 探讨自由基损伤与前列腺癌(Pca)、良性前列腺增生(BPH)发病的关系。方法 分别将前列腺癌、良性前列腺增生组织及正常前列腺(NP)组织匀浆,检测组织中总超氧化物岐化酶(T-SOD)、过氧化氢酶(CAT)和丙二醇(MDA)的含量。结果 Pca组织中T-SOD、CAT活性均较BPH组织和NP组织高,而T-SOD、CAT活性在BPH和NP无显著差别;三种组织中MDA的含量差别显著,依次为BPH>NP>Pca。结论 活性氧和羟自由基与Pca、BPH发病过程可能有一定联系。 |
| 关 键 词： | BPH SOD 前列腺组织 恶性 NP 良性前列腺增生 前列腺癌 过氧化氢酶（CAT） 活性氧 超氧化物岐化酶 |
| 修稿时间： | 2000-12-14 |
The changes of the contents of superoxide dismutase,catalase and malondialdehyde in benign and malignant prostatic tissues |
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| LIU Qingyong,DANG Jiangong,NAN Xunyi,et al.. The changes of the contents of superoxide dismutase,catalase and malondialdehyde in benign and malignant prostatic tissues[J]. Journal of MOdern Urology, 2001, 6(1): 22-24 | |
| Authors: | LIU Qingyong DANG Jiangong NAN Xunyi et al. |
| Affiliation: | LIU Qingyong,DANG Jiangong,NAN Xunyi,et al. Department of Urology. The First Hospital of Xi'an Jiao Tong University,Xi'an,710061. |
| Abstract: | Objective To investigate the relationship between free radical and the pathogenesis of prostate carcinoma and benign prostatic hyperplasia. Methods The contents of total superoxide dismutase(T -SOD),catalase(CAT)and malondiaodehyde(MDA)were detected in the prostate carcinoma (Pea) .benign pro-static hypcrplasia(EPH)and normal prostate( NP)tissues. Results The activities of T - SOD and CAT in Pea were significantly higher than these in BPH and NP, but there was not significant difference between. BPH and NP. The contents of MDA were significantly different in BPH , NP and Pea tissues (BPH> NP> Pea). Conclusions Active oxygen, hydroxide free redical and lipid peroxidation may be relative to the developing of Pea and BPH. |
| Keywords: | Benign prosraric hyperplasia Prostate carcinoma Superoxide dismutase Cataiase Malondialdehyde. |
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