中重度血小板减少对妊娠结局的影响

目的探讨中重度血小板减少对妊娠结局的影响。方法选择2010年10月～2012年9月首都医科大学附属复兴医院收治的妊娠合并血小板减少的126例患者（研究组）的临床资料进行回顾性分析,选取同期无血小板减少患者130例（对照组）为研究对象,观察并比较两组产妇的血小板减少的病因、产妇的并发症、分娩结局以及新生儿出生后情况等指标。结果发病原因中以妊娠相关性血小板减少最高,共79例。研究组剖宫产率、引产率分别为60.09%、30.95%,对照组分别为58.46%、7.69%,两组间比较,差异有统计学意义（P〈0.05）。研究组的羊水污染、死胎的发生率明显高于对照组,两组间比较两者差异有统计学意义（P〈0.05）;而新生儿死亡和胎儿宫内发育迟缓的发生率,两组间比较差异无统计学意义（P〉0.05）。重度血小板减少组患儿1、5 minApgar〈7分及围生期死亡的发生率均高于中度血小板减少组,两组间比较差异有统计学意义（P〈0.05）。结论中重度血小板减少可加重母婴的不良妊娠结局,加重胎儿及新生儿的死亡,且与病情呈正相关。

Influence of moderate and severe platelet less to the pregnancy outcome

Objective To explore the influence of moderate and severe platelet less to the pregnancy outcome.Methods The clinical data of 126 cases（study group） of pregnancy with thrombocytopenia patients from October 2010 to September 2012 in Fuxing Hospital Affiliated to Capital Medical University were retrospectively analyzed,at the same time,the 130 cases（control group） without thrombocytopenia patients were selected as the research object,the maternity thrombocytopenic etiology,maternal complications,delivery end and neonatal birth situation after the index were observed and compared between the two groups.Results The gestational thrombocytopenia was the highest cause,a total of 79 cases.The rate of cesarean section and directing the production induction rate was 60.09% and 30.95% in study group,the control group was 58.46% and 7.69%,the two groups were compared,the difference had statistical significance（P 0.05）.The team of amniotic fluid pollution,the incidence of stillbirth was obviously higher than that of the control group,the two groups were compared,the difference was statistically significance（P 0.05）;and neonatal death and fetal intrauterine growth retardation incidence,the two groups were compared,the difference had no sense of statistics（P 0.05）.The 1,5 min Apgar 7 points in the perinatal period and the incidence of death in severe thrombocytopenia patients group were higher than those of moderate thrombocytopenia group,the two groups were compared,the difference had statistical significance（P 0.05）.Conclusion Moderate and severe thrombocytopenia may increase the rate of maternal adverse pregnancy,aggravating fetal and neonatal death,and positive correlation with illness.