| 尼泊尔酸模中分离到的1个新萘酮类化合物 |
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| 引用本文： | 邓丽娜,李博然,王睿,王国伟,董召月,廖志华,陈敏.尼泊尔酸模中分离到的1个新萘酮类化合物[J].中国中药杂志,2017,42(16):3143-3145. |
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| 作者姓名： | 邓丽娜 李博然 王睿 王国伟 董召月 廖志华 陈敏 |
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| 作者单位： | 西南大学 药学院 发光与实时分析化学教育部重点实验室(西南大学), 重庆 400715,重庆市中药研究院 重庆市中药资源学重点实验室, 重庆 400065,西南大学 药学院 发光与实时分析化学教育部重点实验室(西南大学), 重庆 400715,西南大学 药学院 发光与实时分析化学教育部重点实验室(西南大学), 重庆 400715,西南大学 药学院 发光与实时分析化学教育部重点实验室(西南大学), 重庆 400715,西南大学 生命科学学院, 重庆 400715,西南大学 药学院 发光与实时分析化学教育部重点实验室(西南大学), 重庆 400715 |
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| 基金项目： | 国家自然科学基金项目（31360069，31660097，21662011）；海南省高校科研项目（HNKY2014-41）；教育部创新团队的项目（IRT-16R19） |
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| 摘 要： | 对尼泊尔酸模根的化学成分进行研究。综合运用多种色谱分离技术对尼泊尔酸模根的乙酸乙酯萃取物进行分离纯化,通过核磁共振和高分辨质谱等波谱学分析方法确定化合物的结构。该研究从尼泊尔酸模根中分离到1个新萘酮类化合物,命名为酸模酮A(1),并采用人肺癌细胞A549、人肝癌细胞HepG2、人胃癌细胞SGC7901、人乳腺癌细胞MDA-MB-231评价其体外细胞毒性。
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| 关 键 词： | 尼泊尔酸模 蓼科 酸模酮 A 化学成分 |
| 收稿时间： | 2017/5/17 0:00:00 |
A new napthalenone from roots of Rumex nepalensis |
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| DENG Li-n,LI Bo-ran,WANG Rui,WANG Guo-wei,DONG Zhao-yue,LIAO Zhi-hua and CHEN Min.A new napthalenone from roots of Rumex nepalensis[J].China Journal of Chinese Materia Medica,2017,42(16):3143-3145. |
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| Authors: | DENG Li-n LI Bo-ran WANG Rui WANG Guo-wei DONG Zhao-yue LIAO Zhi-hua and CHEN Min |
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| Institution: | Key Laboratory of Luminescent and Real-Time Analytical Chemistry(Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China,Chongqing Key Laboratory of Chinese Traditional Medicine Resource, Chongqing Academy of Chinese Materia Medica, Chongqing 400065, China,Key Laboratory of Luminescent and Real-Time Analytical Chemistry(Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China,Key Laboratory of Luminescent and Real-Time Analytical Chemistry(Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China,Key Laboratory of Luminescent and Real-Time Analytical Chemistry(Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China,School of Life Sciences, Southwest University, Chongqing 400715, China and Key Laboratory of Luminescent and Real-Time Analytical Chemistry(Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China |
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| Abstract: | A new napthalenone, rumexone A (1), was isolated from the roots of Rumex nepalensis. The structure of 1 was elucidated by extensive spectroscopic analyses, including 1D and 2D NMR spectra and MS data. Its cytotoxic effect was evaluated using four clinically relevant human cancer cell lines, gastric carcinoma SGC7901, breast carcinoma MDA-MB-231, lung carcinoma A549, and hepatocellular carcinoma HepG2. |
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| Keywords: | Rumex nepalensis Polygonaceae rumexone A chemical constituent |
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