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| 安博立酸对人胃癌细胞系SGC-7901增殖抑制作用研究 | |
| 引用本文： | 施建民,孙 婧,张国铎,禹立霞,钱晓萍,刘宝瑞. 安博立酸对人胃癌细胞系SGC-7901增殖抑制作用研究[J]. 南京医科大学学报(自然科学版), 2009, 29(4): 445-449 |
| 作者姓名： | 施建民 孙 婧 张国铎 禹立霞 钱晓萍 刘宝瑞 |
| 作者单位： | 南京大学医学院附属鼓楼医院肿瘤中心,江苏南京,210008 |
| 摘 要： | 目的:观察安博立酸(Ambrolic acid,AmbA)对人胃癌细胞SGC-7901增殖和凋亡的影响,初步探讨AmbA对胃癌的体外抗肿瘤活性.方法:将AmbA作用于SGC-7901细胞株,MTT法测定AmbA对SGC-7901细胞增殖的抑制率;光学显微镜观察AmbA作用引起的细胞形态变化;流式细胞仪检测AmbA作用后细胞凋亡情况及进行细胞周期分析.结果:MTT实验结果表明,AmbA对SGC-7901细胞增殖有抑制作用,其抑制效应具有时间及浓度依赖性;流式细胞仪检测分析表明.AmbA可使细胞阻滞于S期,其作用呈剂量依赖性.结论:AmbA对SGC-7901人胃癌细胞的生长具有明显的抑制作用,其作用的主要途径可能是使细胞阻滞于S期并诱导细胞凋亡. |
| 关 键 词： | 安博立酸 胃癌细胞 细胞周期 凋亡 |
| 收稿时间： | 2008-10-31 |
Inhibitory effects of Ambrolic Acid on cell proliferation in human gastric carcinoma cell line SGC-7901 |
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| SHI Jian-min,SUN Jing,ZHANG Guo-duo,YU Li-xi,QIAN Xiao-ping and LIU Bao-rui. Inhibitory effects of Ambrolic Acid on cell proliferation in human gastric carcinoma cell line SGC-7901[J]. Acta Universitatis Medicinalis Nanjing, 2009, 29(4): 445-449 | |
| Authors: | SHI Jian-min SUN Jing ZHANG Guo-duo YU Li-xi QIAN Xiao-ping LIU Bao-rui |
| Affiliation: | Department of Oncology;Drum Tower Hospital Affiliated to Nanjing University;Nanjing 210008;China |
| Abstract: | Objective:To explore the effects of Ambrolic acid(AmbA) on proliferation and apoptosis of human gastric cancer SGC-7901 cell line.Methods:MTT assay was used to observe the anti-proliferation effect of AmbA on SGC-7901 cells with morphological changes observed under optical microscopy at the same time.The apoptosis rates and cell cycle status of SGC-7901 cells treated by AmbA were determined by flow cytometry(FCM).Results:AmbA inhibited the proliferation of SGC-7901 cells in a dose and time-dependent manner.... |
| Keywords: | ambrolic acid gastric cancer cell cell cycle apoptosis |
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