红霉素在慢性阻塞性肺疾病气道炎症中的作用

目的:探讨红霉素在慢性阻塞性肺疾病(COPD)气道炎症中的作用。方法:复制COPD大鼠动物模型,用红霉素治疗和预防治疗。采用HE染色观察病理形态学变化,ELISA法测定血清中IL-1β、TNF-!的水平。结果:与模型组比较,给予红霉素治疗和预防治疗后,BALF中的中性粒细胞数百分比明显减少,气道壁的炎症反应明显减轻,血清中IL-1β、TNF-"水平显著下降。结论:红霉素能够部分减轻气道炎症反应,其机制主要与通过抑制中性粒细胞聚集与活化,抑制炎症细胞分泌IL-1β、TNF-#有关。

Effectiveness of Erythromycin in Chronic Obstructive Pulmonary Diseases

Objective:To investigate the role of erythromycin on airway inflammation in chronic obstructive pulmonary disease (COPD). Method:COPD model was established using rats. The protective and therapeutic effects of erythromycin (EM) were evaluated. The pathomorphological changes were observed with HE staining. The levels of interleukin-1(IL-1)β and tumor necrosis factor-α(TNF-α) in serum were detected by ELISA . Results:After treatment or prevention with EM, the percentages of neutrophils in BALF from model group were higher than those from control group. The inflammation on airway wall was significantly decreased and the levels of IL-1β and TNF-αin serum were significantly reduced as compared to those in model group. Conclusion:EM may prevent airway inflammation to some degree by including to inhibit the aggregation and activation of neutrophils and to release IL-1β and TNF-α.