不同病因尿毒症患者肱动脉内-中膜厚度与内皮舒张功能的临床研究

[目的]探讨不同病因所致尿毒症行维持性血液透析(MHD)患者肱动脉内-中膜厚度(IMT)与内皮舒张功能(EDD)间有无差异.[方法]应用高分辨率超声诊断仪,对51例应用动静脉内瘘行MHD的尿毒症患者(其中高血压肾病所致16例、糖尿病肾病所致15例、慢性肾小球肾炎所致20例)和30例正常对照组,检测尿毒症MHD患者无动静脉内瘘侧肱动脉及健康人右侧肱动脉IMT、基础内径、反应性充血后内径并计算肱动脉EDD.[结果]在高血压肾病、糖尿病肾病和慢性肾小球肾炎所致尿毒症MHD患者中,三组的EDD与健康对照组比较(14.98±4.87)%,差异有显著性意义(P<0.01);糖尿病肾病组的EDD(4.78±0.85 )%与高血压肾病组(7.39±1.54)%和慢性肾小球肾炎组(7.81±2.11 )%比较,差异有显著性意义(P<0.01),高血压肾病组与慢性肾小球肾炎组EDD比较,差异无显著性意义(P>0.05).高血压肾病组(0.38±0.10) mm、糖尿病肾病组(0.46±0.07) mm、慢性肾小球肾炎组(0.40±0.10) mm的IMT与健康对照组(0.28±0.09) mm比较,差异有显著性意义(P<0.01);三组病例组间的IMT比较,差异无显著性意义(P>0.05).[结论]不同病因所致尿毒症MHD患者中,糖尿病肾病所致尿毒症EDD受损最严重,而三组病例组间IMT无差异.

Study of intima-media thickness of brachial artery and endothelial function in patients with uremia

[Objective] The study examines the brachial artery intima-media thickness(IMT)and endothelium-dependent dilation(EDD) in patients with maintenance hemodialysis(MHD)of uremia.[Methods] With high frequency ultrasound,the brachial artery IMT and EDD in 51 patients with arterio-venous fistula of MHD of uremia were evaluated.Of them,16 had hypertentive nephropathy,15 had diabetic nephropathy and 20 had chronic glomerulonephritis.Thirty healthy subjects were selected as control.Measurements of brachial artery IMT...