周剂量多西紫杉醇联合顺铂和5-氟尿嘧啶治疗晚期胃癌

  目的 观察周剂量多西紫杉醇联合顺铂（DDP）、5-氟尿嘧啶（5-Fu）治疗晚期胃癌的临床疗效和毒副作用。方法 晚期胃癌患者28例，给予多西紫杉醇35 mg／m2，静脉滴注1 h，第1、8、15天；DDP 75 mg／m2，均分第1 ~ 3天静脉滴注，5-Fu 500 mg／m2，24 h中心静脉置泵持续滴注，第1 ~ 5天，28 d为1个周期。化疗2 ~ 6个周期后按WHO实体瘤疗效评价标准（RECIST）评定疗效，按WHO标准评价不良反应。结果 全组28例均可评价疗效，其中完全缓解（CR）2例，部分缓解（PR）13例，稳定（SD）7例，近期客观有效率53.4 %，中位疾病进展时间（TTP）为8.7个月，中位生存期（MS）为11.8个月，1年生存率为47.8 %。主要不良反应为骨髓抑制和胃肠道反应。但Ⅲ ~ Ⅳ度发生率较低。结论 周剂量多西紫杉醇联合DDP和5-Fu治疗晚期胃癌疗效较好，患者毒副作用轻，耐受性好，值得进一步推广使用。

A study of weekly docetaxel combined with cisplatin/5-fluorouracil chemotherapy for patients with advanced gastric cancer(AGC)

Objective To investigate the clinical value and toxicity of weekly docetaxel combined with cisplatin / 5-fluorouracil chemotherapy for patients with advanced gastric cancer(AGC). Methods Twenty eight patients with advanced gastric cancer(AGC) were treated with weekly docetaxel 35mg/m2 iv infu－sion for 1 hour in the first, eighth, and fifteenth days combined with DDP 75 mg/m2 iv infusion in three days and 5-Fu 500 mg/m2 continuous intravenous infusion for 24 h from the first to the fifth day, and repeat the regimen every 28 days. The efficacy and toxicity was evaluated after 2~6 cycles. Results Twenty eight pa－tients were evaluated for clinical response: CR 2 cases, PR 13 cases, SD 7 cases. The clinical beneficial re－sponse rate was 53.4 %. Median time to progression (TTP) was 8.7 months and median survival time was 11.8 months, the overall 1-year survival rate was 47.8 %. The main side effects were bone marrow suppression and nausea. Conclusion Chemotherapy of weekly docetaxel combined with cisplatin /5-fluorouracil is an effec－tive and well tolerated regimen in the treatment of AGC.