Oxygen free radicals and pelvic adhesion formation: I. Blocking oxygen free radical toxicity to prevent adhesion formation in an endometriosis model. |
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| Authors: | D M Portz T E Elkins R White J Warren S Adadevoh J Randolph |
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| Affiliation: | University of Michigan Medical Center, Department of Obstetrics and Gynecology, Ann Arbor. |
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| Abstract: | Intraperitoneal superoxide dismutase (SOD) and catalase were used to block the toxic effects of superoxide anion (O2) and hydrogen peroxide (H2O2), associated with the production of endometriosis and inflammation in a rabbit model. In a two-part animal study, the combined instillation of SOD and catalase significantly reduced the formation of intraperitoneal adhesions at endometriosis sites. |
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