| 和解聚散方对单侧输尿管梗阻肾间质纤维化大鼠细胞外基质表达的影响 |
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| 引用本文： | 沈存,王耀献,孙卫卫,崔瑾,刘尚建,王晓楠,吕杰.和解聚散方对单侧输尿管梗阻肾间质纤维化大鼠细胞外基质表达的影响[J].中国中西医结合肾病杂志,2011,12(11):967-969,1036,1037. |
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| 作者姓名： | 沈存 王耀献 孙卫卫 崔瑾 刘尚建 王晓楠 吕杰 |
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| 作者单位： | 1. 北京中医药大学东直门医院,北京,100029
2. 北京中医药大学东直门医院肾内科,北京,100700 |
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| 基金项目： | 国家自然科学基金资助项目(No.30873223/H2704); 北京中医药大学校级自主项目(No.2009JYB22-JS076、2010JYB22-JS063); 教育部中医内科学重点实验室; 卫生部肾病重点专科资助项目 |
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| 摘 要： | 目的:研究和解聚散方对单侧输尿管梗阻(unilateral ureteral obstruction,UUO)大鼠肾间质纤维化(renal interstitial fibrosis,RIF)、细胞外基质(extracellular matrix,ECM)、纤维连接蛋白(FN)和Ⅳ型胶原(Col Ⅳ)表达的影响.方法:...
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| 关 键 词： | 和解聚散方 肾间质纤维化 细胞外基质 |
Effect of Hejiejusan Formula on Expression of ECM in UUO-induced Renal Interstitial Fibrosis Rats |
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| SHEN Cun,WANG Yaoxian,SUN Weiwei,et al Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Beijing.Effect of Hejiejusan Formula on Expression of ECM in UUO-induced Renal Interstitial Fibrosis Rats[J].Chinese Journal of Integrated Traditional and Western Nephrology,2011,12(11):967-969,1036,1037. |
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| Authors: | SHEN Cun WANG Yaoxian SUN Weiwei Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine Beijing |
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| Institution: | SHEN Cun,WANG Yaoxian,SUN Weiwei,et al Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Beijing(100029) |
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| Abstract: | Objective：To study the effect of hejiejusan formula on expression of ECM, including fibronectin（FN） and Collagen Type Ⅳ（Col Ⅳ） in unilateral ureteral obstruction（UUO）-induced renal interstitial fibrosis（RIF） rats.Methods：RIF model rats were established by UUO. All the UUO rats randomly divided into model group, benazepril group, hejiejusan formula group. Healthy rats were chosen as the sham operation group. The rats were killed on the seventh, fourteenth and twenty-one days in batches respectively after UUO. The protein expression of FN and Col Ⅳ in kidney tissues were detected by Immunohistoche- mistry.Results：Compared with model group, the protein expression of FN in hejiejusan formula groups of three time points were all significantly decreased （P0.05）, but Col Ⅳ decreased only in 7 days group（P0.05）.Conclusion：Hejiejusan formula has the function of down-regulating the expression of ECM in RIF rats at three time points after UUO, especially early. It suggests to some extent, the effectiveness and superiority of hejiejusan formula, the correctness of hejiejusan method which is under the guidance of pathogenesis of shenluojusanxiaozhang theory. |
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| Keywords: | Hejiejusan formula Renal interstitial fibrosis Extracellular matrix |
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