| 放疗同期IP方案化疗治疗局部晚期食管癌临床研究 |
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| 引用本文： | 高飞,贾霖,杜辉章,王允,况小红,韩建军. 放疗同期IP方案化疗治疗局部晚期食管癌临床研究[J]. 临床消化病杂志, 2009, 21(3) |
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| 作者姓名： | 高飞 贾霖 杜辉章 王允 况小红 韩建军 |
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| 作者单位： | 四川省绵阳市第三人民医院肿瘤科,绵阳,621000;四川省盐亭县肿瘤医院 |
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| 摘 要： | 目的 探讨放疗同期IP方案化疗治疗局部晚期食管癌的临床疗效及毒性反应.方法 将68例局部晚期食管癌患者随机分为IP方案同期放疗组(研究组)35例和单纯放疗组(对照组)33例.两组放疗均采用常规分割放射治疗,总剂量60 Gy.化疗采用放疗第1天开始伊市替康(国产艾力):第1、8天65 mg/m2静脉点滴;DDP:第1、8天30mg/m2静脉点滴,每21天为1周期,共4周期.结果 研究组治疗晚期食管癌缓解率(91.4%)明显优于单放组(66.7%),两年总生存率及一、二年的无疾病进展生存率前者也明显好于后者,具统计学差异(P<0.05).IP方案组恶心呕吐、骨髓抑制(白细胞减少)和腹泻的发生率高于单放组.结论 IP方案化疗同期放疗治疗局部晚期食管癌疗效肯定,能提高患者生存率,虽毒副反应增加,但患者可耐受,值得临床推广应用.
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| 关 键 词： | 食管癌 伊立替康 放射治疗 副反应 |
A Clinical Study of combination of Radiotherapy and IP Regimen in the Treatment of Patients with Local Advanced Esophageal Cancer |
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| GAO Fei,JIA Lin,DU Hui-zhang,WANG Yun,KUANG Xiao-hong,HAN Jian-jun. A Clinical Study of combination of Radiotherapy and IP Regimen in the Treatment of Patients with Local Advanced Esophageal Cancer[J]. Chinese Journal of Clinical Gastroenterology, 2009, 21(3) |
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| Authors: | GAO Fei JIA Lin DU Hui-zhang WANG Yun KUANG Xiao-hong HAN Jian-jun |
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| Affiliation: | GAO Fei,JIA Lin,DU Hui-zhang,WANG Yun,KUANG Xiao-hong,HAN Jian-junThe Tthird Hospital of Mianyang,Mianyang,621000,China The Tumor Hospital of Yanting |
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| Abstract: | Objective To study the clinical efficacy and toxicity of combination of the radiotherapy and IP regimen for patients with local advanced esophageal cancer.Methods 68 cases with local advanced esophageal cancer were randomized into two groups:simple irradiation group(control group,n=33)receiving conventional radiotherapy to a total of 60 Gy,combined group(research group,n=35)which received the same radiotherapy as simple irradiation group plus chemotherapy with IP regimen,patients in research group were trea... |
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| Keywords: | Esophageal cancer Irinotecan Radiotherp Adverse efects |
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