siRNA-mediated inhibition of phosphatidylinositol glycan Class B (PIGB) confers resistance to methylmercury in HEK293 cells |
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| Authors: | Hwang Gi-Wook Hayashi Tatsuya Kita Kayoko Takahashi Tsutomu Kuge Shusuke Naganuma Akira |
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| Affiliation: | Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan. |
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| Abstract: | ![]()
We performed functional gene screening, using a siRNA library targeting 8,500 human genes, to identify proteins that are involved in the susceptibility of cells to methylmercury. Screening revealed that downregulation of the gene for phosphatidylinositol glycan class B (PIGB) by siRNA confers resistance to methylmercury in HEK293 cells. |
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