| 8种不同转移潜能人癌细胞系中nm23基因的表达 |
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| 引用本文： | 李珊珊,方伟岗,闫爱华,任秀花,沈琼. 8种不同转移潜能人癌细胞系中nm23基因的表达[J]. 郑州大学学报(医学版), 2000, 35(2): 110-112 |
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| 作者姓名： | 李珊珊 方伟岗 闫爱华 任秀花 沈琼 |
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| 作者单位： | 河南医科大学第一附属医院病理科,河南省肿瘤病理学重点实验室,郑州,450052;北京医科大学病理系,北京,100083;河南医科大学癌前期研究室,郑州,450052 |
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| 基金项目： | 国家博士研究生科研项目,, |
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| 摘 要： | 目的:探讨肿瘤转移抑制基因nm23在人前列腺癌细胞、肺癌细胞和人黑色素瘤细胞系中的转移抑制作用.方法:应用Northern blot杂交法检测8种不同转移潜能人癌细胞中(PC3,PC3M,PAa,PG,WM35,WM1341b,WM983a和WM451) nm23基因的表达.结果:nm23 mRNA在8种不同转移潜能的人癌细胞中都有表达,且nm23表达水平也未见差异.结论:nm23基因可能与这些细胞系(前列腺癌细胞、肺癌细胞及黑色素瘤) 的转移抑制无关.
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| 关 键 词： | nm23基因 基因 抑制 肿瘤转移 肿瘤细胞 Northern印迹 |
| 修稿时间： | 1999-12-25 |
Expressions of nm23 gene in eight human cancer cell lines with different metastatic potentials |
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| LI Shanshan,FANG Weigang,YAN Aihua,REN Xiuhua,SHEN Qiong. Expressions of nm23 gene in eight human cancer cell lines with different metastatic potentials[J]. Journal of Zhengzhou University(Medical Sciences), 2000, 35(2): 110-112 |
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| Authors: | LI Shanshan FANG Weigang YAN Aihua REN Xiuhua SHEN Qiong |
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| Affiliation: | LI Shanshan(Department of Pathology,the First Affiliated Hospital,Henan Medical University,Zhengzhou450052)FANG Weigang(Department of Pathology,Beijing Medical University,Beijing 100083)YAN Aihua,REN Xiuhua,SHEN Qiong(Department of Precancerous Studies,Henan Medical University,Zhengzhou 450052) |
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| Abstract: | Aim:To investigate the nm23 gene suppression of metastasis in human prostate cancer, lung cancer and melanoma cell lines Methods:Expressions of nm23 gene in eight human cancer cell lines, PC3, PC3M, PAa, PG, WM35, WM1341b, WM983a and WM451,with different metastasis potentials were studied by Northern blot hybridization Results:mRNA of nm23 all expressed in eight human cancer cell lines with different metastasis potentials and no difference in nm23 expression levels was observed in these cancer cell lines Conclusion:nm23 gene may not correlate with metastatic suppression of these cancer cell lines(human prostate and lung cancer cells,and human melanoma cells) |
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| Keywords: | nm23 gene gene suppressor neoplasm metastasis human cancer cell Northern blot |
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