杠板归化学成分的分离与鉴定

目的对杠板归(Polygonum perfoliatumL.)的化学成分进行分离与鉴定。方法对杠板归体积分数为70%的乙醇提取物的乙酸乙酯萃取部分和正丁醇萃取部分进行分离,通过理化性质和波谱分析鉴定化合物的结构。结果得到7个化合物,分别鉴定为山萘酚(kaempferol,1)、槲皮素(quercetin,2)、蓄苷(avicularin,3)、槲皮素-3-O-β-D-葡萄糖醛酸甲酯(quercetin-3-O-β-D-glu-curonide 6-″methyl ester,4)、槲皮素-3-O-β-D-葡萄糖醛酸正丁酯(quercetin-3-O-β-D-glucuronide 6″-butyl ester,5)、山萘酚-3-O-芸香糖苷(kaempferol-3-O-rutinoside,6)、芦丁(rutin,7)。结论化合物5为首次从该属植物分离得到;化合物3、67、为首次从该植物中分离得到。

Isolation and identification of chemical constituents of Polygonum perfoliatum L.

Abstract: Objective To study the chemical constituents of Polygonum perfoliatum L. Methods The constituents of the ethyl acetate-soluble and n-BuOH-soluble portions of the 70% ethanol extract of Polygonum perfoliatum L. were isolated and purified by various chromatographic methods. The structures were confirmed on the basis of physico-chemical properrties and spectroscopic data. Results Seven compounds were isolated and identified as kaempferol(1), quercetin(2), avicularin(3), quercetin-3-O-β-D-glucuronide 6′′-methyl ester(4), quercetin- 3-O-β-D-glucuronide 6′′-butyl ester(5), kaempferol-3-O-rutinoside(6) and rutin(7). Conclusion Compound 5 is obtained from this genus for the first time; Compounds 3, 6 and 7 are isolated from this plant for the first time.