阿立哌唑与氯丙嗪治疗女性精神分裂症对照研究

目的：探讨阿立哌唑与氯丙嗪对女性精神分裂症患者的疗效及安全性。方法：对68例女性精神分裂症患者随机分为两组，分别给予阿立哌唑与氯丙嗪治疗，疗程8周。用阳性与阴性症状量表（PANSS）与副反应量表（TESS）评定疗效和不良反应。结果：两组总的疗效差异无显著性（P〉0．05），但阿立哌唑起效较快；且在治疗阴性症状方面，以阿立哌唑显著较好（P〈0．05）。阿立哌唑组不良反应较氯丙嗪组少，其中震颤、静坐不能、视物模糊、心动过速显著少于氯丙嗪组（P〈0．05）。结论：阿立哌唑是一种安全有效的抗精神病药。

Comparative study between aripiprazole and chlorpromazine in the treatment of female patients with schizophrenia

Objective:To detect the clinical efficacy and side effects of aripiprazole and chlorpromazine in the treatment of female schizophrenic patients.Methods:68 female schizophrenic patients have been divided into aripiprazole group and chlorpromazine group randomly to treat for 8 weeks.Positive and negative syndrome scale(PANSS) and treatment emergent symptom scale(TESS) were used to evaluate the efficacy and side effects respectively.Results: There were no significant difference between two groups(P>0.05).However,Aripiprazole took effect more quickly.But,Significant difference were found between two groups in the reduction rate of scale about negative symptoms(P<0.05).Patients in aripiprazole group reported much fewer side effects than those in chlorpromazine group,especially in the items of tremor,skathisia,blur sight and tachycardia on TESS(P<0.05).Conclusions: Aripiprazole is an effective antipsyshotic drug with fewer side effects.