地塞米松联合长春西汀和胞磷胆碱钠治疗突发性耳聋的临床疗效

目的探讨注射用地塞米松磷酸钠联合长春西汀注射液和胞磷胆碱钠氯化钠注射液治疗突发性耳聋的临床疗效。方法选取2016年5月—2017年5月海安县医院收治的突发性耳聋患者112例为研究对象,按照数表法将患者随机分为对照组和治疗组,每组各56例。对照组静脉滴注胞磷胆碱钠氯化钠注射液,0.5 g加入到0.9%氯化钠溶液250 m L中,1次/d;且对照组缓慢静脉滴注长春西汀注射液,30 mg加入到0.9%氯化钠溶液500 m L中,1次/d。治疗组在对照组基础上静脉滴注注射用地塞米松磷酸钠,10 mg加入到5%葡萄糖溶液250 m L中,1次/d,3 d后剂量调整为5 mg/次。两组患者均连续治疗7~10 d。观察两组的临床疗效,比较两组的听力指标,眩晕、耳鸣发生率和血液流变学。结果治疗后,对照组和治疗组的总有效率分别为85.71%、96.43%,两组比较差异有统计学意义(P0.05)。治疗后,两组平均纯音听阈、低频区听阈和高频区听阈均显著下降,同组治疗前后比较差异具有统计学意义(P0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组耳鸣和眩晕的发生率显著下降,同组治疗前后比较差异具有统计学意义(P0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组全血高切黏度、全血低切黏度和血浆黏度均显著下降,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P0.05)。结论注射用地塞米松磷酸钠联合长春西汀注射液和胞磷胆碱钠氯化钠注射液治疗突发性耳聋具有较好的临床疗效,改善临床症状,调节血液流变学指标,安全性较好,具有一定临床推广应用价值。

Clinical observation of dexamethasone combined with vinpocetine and citicoline sodium in treatment of sudden deafness

Objective To investigate the clinical efficacy of Dexamethasone Sodium Phosphate for injection combined with Vinpocetine Injection and Citicoline Sodium and Sodium Chloride Injection in treatment of sudden deafness. Methods Patients (112 cases) with sudden deafness in Hai''an County People''s Hospital from May 2016 to May 2017 were randomly divided into control and treatment groups, and each group had 56 cases. Patients in the control group were iv administered with Citicoline Sodium and Sodium Chloride Injection, 0.5 g added into normal saline 250 mL, once daily. And patients in the control group were also iv administered with Vinpocetine Injection, 30 mg added into normal saline 500 mL, once daily. Patients in the treatment group were iv administered with Dexamethasone Sodium Phosphate for injection on the basis of the control group, 10 mg added into 5% glucose solution 250 mL, once daily, and the dose was adjusted to 5 mg/time after 3 d. Patients in two groups were treated for 7-10 d. After treatment, the clinical efficacies were evaluated, and hearing indexes, the incidence rates of vertigo and tinnitus, and hemorheology in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 85.71% and 96.43%, respectively, and there was difference between two groups (P<0.05). After treatment, the average pure tone threshold, low frequency threshold, and high frequency region threshold in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the incidence of tinnitus and vertigo in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the whole blood high shear viscosity, whole blood low shear viscosity, and plasma viscosity in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Dexamethasone Sodium Phosphate for injection combined with Vinpocetine Injection and Citicoline Sodium and Sodium Chloride Injection has clinical curative effect in treatment of sudden deafness, can improve clinical symptoms, and can regulate blood rheology indexes, with good safety, which has a certain clinical application value.