洛阳市肝癌危险因素的病例对照研究

目的：探讨中国肝癌低发区肝癌的危险因素，为肝癌的预防提供科学依据。方法：采用病例对照研究设计，以50例肝癌患者和73例健康对照作为研究对象，询问其暴露史，然后应用SAS软件进行单因素和多因素非条件logistic回归分析。结果：单因素非条件logistic回归分析表明，乙肝病史、亲属肿瘤史、疟疾、水果、吸烟是肝癌的危险因素，其比值比分别为９９．４３、７．４６、３．８０、２．９０和２．３５；月经异常是女性肝癌的危险因素，其比值比为4．25；蔬菜和自来水是肝癌的保护因素，其比值比分别为0．42和0．14。多因素非条件logistic回归分析表明，乙肝病史、亲属肿瘤史、疟疾、精神创伤、吸烟和油炸食品是肝癌的危险因素，其比值比分别为89．23、35．52、17．19、3．88、4．39和4．27；20年前生活水平是肝癌的保护因素，其比值比为0．23。讨论内容：肝癌是多因素所致的恶性肿瘤；水果成为肝癌的危险因素，可能是患乙肝后所致的偏倚；首次报告油炸食品和月经异常与肝癌的关联。

THE CASE-CONTROL STUDY FOR THE RISK FACTORS OF HCC IN LUOYANG

Objective:To explore the risk factors of HCC in the areas of low incidence for HCC in China and provide proofs for control of HCC.Methods:Using the design of case control study, 50 patients with HCC and 73 healthy controls were selected as the subjects, whose exposure histories were inquired. Monofactorial and multifactorial non conditioning logistic regressive analyses were carried out.Results:The results of monofactorial non conditioning logistic regressive analysis showed that history of hepatitis B, history of cancers in the relatives, history of malaria, eating fruits habitually and smoking were the risk factors for HCC, and their odds ratios were 99 43, 7 46, 3 80, 2 90 and 2 35,respectively, that abnormal menstruation was the risk factor for HCC in women, and its odds ratio was 4 25, that eating vegetables habitually and drinking tap water were the protective factors for HCC, and their odds ratios were 0 42 and 0 14,respectively. The results of multifactorial non conditioning logistic regressive analysis showed that history of hepatitis B, history of cancers in the relatives, history of malaria, history of psychic trauma, smoking and eating fried foods habitually were the risk factors for HCC, and their odds ratios were 89 23,35 52, 17 19, 3 88, 4 39 and 4 27,respectively, and that higher living status 20 years before was the protective factor for HCC, and its odds ratio was 0 23. Conclusions:HCC is a kind of malignancy resulted from the multifactors.Fruits was the risk factor and may be the bias resulted into hepatitis B. It is first reported that eating fried foods habitually and abnormal menstruation are associated with HCC.