亚急性重症肝炎与淤胆性肝炎黄疸成因的组织学差别

对29例亚急性重症肝炎及13例次淤胆性肝炎肝穿刺标本的光、电镜检查,测算了18例亚急性重症肝炎,9例淤胆性肝炎肝细胞内淤胆的容积百分比、胆汁凝固性坏死的容积百分比与临床资料进行统计学处理,指出这两类肝炎都有肝细胞内淤胆和胆汁凝固性坏死,但淤胆性肝炎肝小叶结构完整,胆汁流出道不破坏,亚急性重症肝炎肝小叶破坏。认为除肝细胞大量坏死外,胆汁流出道破坏是影响预后的另一个重要因素。本文详细描述了胆计凝固性坏死的超微结构改变。

COMPARISON OF HISTOPATHOLOGIC CHANGES RELATED TO THE DEVELOPMENT OF JAUNDICE IN SUBACUTE SEVERE HEPATITIS AND BILIARY HEPATITIS

Needle biopsy specimens from 18 subacute severe hepatitis patients (SSH) and 9 biliary hepatitis patients ( BH ) were studied under optic and eltron microscopes. The volume percentage of hepatic cell cholestasis and that of chole-coagulative necrosis were determined. The data obtained were processed statistically for correlation with serai bilirubin contents. The results showed ( 1 ) Hepatic cell cholestasis and chole-coagulative necrosis were present in both SHH and BH) correlation of bilirubin content was only found with hepatic cell "cholestasis in BH. ( 2 ) The architecture of lobules was intact in BH, but destroyed in SSH. ( 3 ) The bile excretory system was preserved in BH.The authors believe that in addition to the extent of liver cell necrosis, the condition of bile excretory system is of prognostic significance to the illness. The ultrastructural details of chole-coagulative necrosis are decribed in this paper