B型尿钠肽和C反应蛋白联合检测在COPD急性加重期合并心衰中的临床意义

目的通过检测慢性阻塞性肺疾病(COPD)急性加重期合并心衰患者血清中B型尿钠肽(BNP)和C反应蛋白(CRP)浓度变化,旨在探讨BNP和CRP在COPD急性加重期合并心衰患者中的临床意义。方法采用微粒子酶法和酶联免疫吸附法,对80例治疗前不同程度COPD急性加重期合并心衰患者BNP和CRP浓度进行检测,并与治疗后COPD急性加重期合并心衰患者(即稳定期)及对照组(健康人群)浓度作比较。结果治疗前COPD急性加重期合并心衰患者BNP和CRP较对照组高,差异有统计学意义(P0.01)。随着病情的加重,血清中BNP和CRP水平也显著升高。治疗后COPD急性加重期合并心衰患者与对照组比较,差异有统计学意义(P0.05)。结论血清中BNP和CRP可作为判断COPD急性加重期合并心衰患者病情严重程度及估计预后的指标之一。

Clinical significance of combined detection of B-type natriuretic peptide and C-reactive protein in acute exacerbation of COPD complicated by heart failure

[Objective]By detecting the changes of serum contents of B-type natriuretic peptide(BNP) and C-reactive protein(CRP) in acute exacerbation of COPD complicated by heart failure,to study the clinical significance of BNP and CRP in acute exacerbation of COPD complicated by heart failure.[Methods]By using MEIA and ELASA,the contents of BNP and CRP were detected in 80 patients with different degrees of acute exacerbation of COPD complicated by heart failure before treatment.The results were compared with the contents of patients after treatment and the controls(healthy population).[Results]The contents of BNP and CRP of patients before treatment were significantly higher than those of the control group(P<0.01).The contents of BNP and CRP increased with the degree of severity.There was significant difference between patients after treatment and the control group(P<0.05).[Conclusion]The serum contents of BNP and CRP can be used as one of the indicators for estimating degree of disease and predicting the prognosis in acute exacerbation of COPD complicated by heart failure.