非甾体类抗炎药相关性上消化道出血的临床特征分析

目的：探讨非甾体类抗炎药（Non-Steroidal Anti-Inflammatory Drugs，NSAIDs）相关性上消化道出血的临床特征。方法选择因呕血或黑便就诊并行急诊胃镜检查确诊的144例患者，分为NSAIDs组和非NSAIDs组，将两组患者进行分析比较。结果NSAIDs组患者年龄≥60岁占67.7%、有消化道症状占32.3%、有心脑血管病史占61.3%、胃镜下糜烂性胃炎和胃溃疡占92.0%、HP 阳性占25.8%，与非 NSAIDs 组比较，差异有统计学意义（P〈0.05）；而 NSAIDs 组患者男性占54.8%、呕血占22.6%，与非NSAIDs组比较，差异无统计学意义（P〉0.05）。结论非甾体类抗炎药是上消化道出血的重要病因，伴有心脑血管疾病或病史的老年患者多见，多不伴有消化道症状和HP感染，且以胃溃疡居多。

Clinical Features Analysis of Upper Gastrointestinal Hemorrhage Caused by Non-steroidal Anti-inflammatory Drugs

Objective To study the clinical features of upper gastrointestinal hemorrhage caused by non-steroidal anti-inflammato-ry drugs（NSAIDs）.Methods 144 visited patients because of haematemesis or melena and diagnosed by emergency endoscopy were divided into NSAIDs group and non-NSAIDs group. And the patients were analyzed and compared. Results Of the NSAIDs group, patients who were 60 years or older accounted for 67.7%, had gastrointestinal symptoms accounted for 32.3%, with the history of cardiovascular or cerebrovascular diseases accounted for 61.3%, erosive gastritis and gastric ulcer detected by gastroscope account-ed for 92.0%, HP positive rate was 25.8%, compared with those of the non-NSAIDs group, the differences were statistically signifi-cant （P〈0.05）; in the NSAIDs group, males accounted for 54.8%, haematemesis accounted for 22.6%, compared with those of the non-NSAIDs group, the differences were not statistically significant（P〉0.05）. Conclusion NSAIDs are an important cause of upper gastrointestinal hemorrhage, the elderly suffering from or having the history of cardiovascular and cerebrovascular disease are easy to find. They have a higher frequency of gastric ulcer. But they have a lower frequency of gastrointestinal symptoms and HP infection .