卡前列甲酯栓预防高危因素剖宫产出血的临床研究

目的：探讨在有出血高危因素的剖宫产术中应用卡前列甲酯栓（卡孕栓）是否能有效减少术中及术后出血，了解卡孕栓在预防剖宫产术中术后出血的效果。方法2013年7月-2014年2月在我院产科选择有出血高危因素的剖宫产产妇400例，随机分为卡孕栓＋缩宫素组及缩宫素组各200例。卡孕栓组在胎儿娩出后，胎盘娩出前予卡孕栓1 mg舌下含化及缩宫素20单位宫体注射；缩宫素组予缩宫素20单位宫体注射。记录2组术中、产后2 h、产后24 h出血量。结果卡孕栓组术中、产后2 h、产后24 h出血量比缩宫素组显著减少。结论卡孕栓可以有效减少有出血高危因素剖宫产术中术后出血，且用药安全。

Clinical investigation of carboprost in prevention of risky postpartum hemorrhage in cesarean section

Objective To investigate the clinical effect of carboprost in prevention of risky intra-operative and postopera-tive bleeding in cesarean section .Methods 400 cases of cesarean section parturients with high postpartum hemorrhage risk were chosen in our hospital from July 2013 to February 2014 and were randomly divided into a carboprost ＋oxytocin group and a oxytocin group,each with 200 cases.For the carboprost ＋oxytocin group,sublingual carboprost 1mg and 20 units of oxy-tocin injection were administered after fetus delivery and before placental expulsion .For the oxytocin group ,20 units of oxytocin injection were given .The hemorrhage blood volume was recorded intra-operatively ,2 hours and 24 hours after operation .Re-sults The carboprost ＋oxytocin group＇s hemorrhage blood volume was significantly lower than that of the oxytocin group in the above recorded time points .Conclusion Carboprost is proved to be safe and can effectively reduce the risk factors of bleeding after cesarean section .