系统评价中国大陆地区有关淋球菌头孢曲松耐药监测的研究

目的 收集近期国内外发表的有关中国大陆淋球菌头孢曲松耐药监测文献,分析文献的质量及淋球菌的耐药趋势.方法 检索中国期刊全文数据库、PubMed、Cochrane数据库,筛选合格文献进行系统评价.结果 入选46篇文献,共报道10 163株淋球菌头孢曲松药敏情况.23篇文献主要来自华南(50%);26篇提供的标准菌株为WHO淋球菌分离株(56.52%);32篇文献药敏试验方法为WHO推荐的琼脂糖稀释法(69.57%);淋球菌的头孢曲松耐药率仍较低,但有增加趋势.结论 应该进一步提高淋球菌耐药监测研究的质量,使之能更好地反映淋球菌耐药状况.

Surveillance of ceftriaxone resistance in Neisseria gonorrhoeae in mainland China: a systematic review

Objective To collect recent refefences with regard to surveillance of ceflriaxone resistance in Neisseria gonorrhoeae in mainland China,and to infer the tendency of ceftriaxone resistance.Methods References were searched in CNKI,PubMed and Cochrane databases,and eligible refefences were ineluded for systematic review.Results Forty-six refefences entered the systematic review in which 10 163 strains were reported.Of them,23 references were from South China (50%).The centrel Neisseria gonorrhoeae strains were from WHO in 26 (56.52%) references.Antimicrobial susceptibility testing was performed by agar dilution method using GC agar base recommended by WHO in 32(69.57%)refefences.The rate of ceflriaxone resistance in Neisseria gonorrhoeae in mainland China was low,but it showed an increasing tendency.Conclusion The quality of surveillance of antibiotic resistance in Neisseria gonorrhoeae should be improved in mainland China to better monitor the situation of ceflriaxone resistance.