Delayed-onset Organizing Pneumonia Emerging after Recovery from Coronavirus Disease 2019: A Report of Three Cases Diagnosed Using Transbronchial Cryobiopsy and a Review of the Literature |
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| Authors: | Sho Nakakubo Keisuke Kamada Yu Yamashita Junichi Nakamura Munehiro Matsumoto Hiroshi Horii Kazuki Sato Daisuke Morinaga Masaru Suzuki Nanase Okazaki Emi Takakuwa Yoshihiro Matsuno Satoshi Konno |
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| Affiliation: | 1.Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan; 2.Department of Surgical Pathology, Hokkaido University Hospital, Japan |
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| Abstract: | ![]()
We present three cases with an atypical clinical course of organizing pneumonia (OP) secondary to coronavirus disease 2019 (COVID-19). Three patients were discharged with satisfactory improvement after standard steroid therapy for COVID-19. Shortly after the completion of treatment, the patients experienced a flare-up of symptoms. Imaging results showed new lesions in the lungs. Transbronchial lung cryobiopsy showed histological findings consistent with OP in all cases. Steroids were administered, and a good therapeutic response was observed. This report is the first to describe pathologically confirmed OP that developed after recovery from COVID-19. Careful follow-up is advisable for patients who have recovered from COVID-19. |
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| Keywords: | COVID-19 organizing pneumonia transbronchial cryobiopsy steroid therapy case report |
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