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| 铅暴露对大鼠学习和记忆的影响 | |
| 引用本文： | 杨新华,周萍,李勇辉. 铅暴露对大鼠学习和记忆的影响[J]. 中国临床心理学杂志, 2007, 15(1): 88-91 |
| 作者姓名： | 杨新华 周萍 李勇辉 |
| 作者单位： | 1. 湖南农业大学心理健康教育中心,湖南,长沙,410128 2. 湖南师范大学教育科学学院,湖南,长沙,410081 3. 中科院心理研究所 |
| 摘 要： | 目的:研究低水平铅暴露对大鼠学习和记忆的影响。方法:0.05%水平醋酸铅污染大鼠饮用水28天,用Morris水迷宫试验测定大鼠的学习记忆功能。结果:在定位导航任务两组之间没有差异(P>0.05);在探索试验和工作记忆任务中,铅暴露组和正常对照组大鼠成绩显著差异(P<0.01)。结论:铅暴露对大鼠空间参考记忆和工作记忆有明显损害作用,对空间学习未见明显影响。 |
| 关 键 词： | 铅暴露 morris水迷宫 参考记忆 工作记忆 |
| 文章编号： | 1005-3611（2007）01-0088-04 |
| 收稿时间： | 2006-06-29 |
| 修稿时间： | 2006-06-29 |
Effect of Lead Exposure on Reference Memory and Working Memory in Rats |
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| YANG Xin-hua,ZHOU ping,LI Yong-hui. Effect of Lead Exposure on Reference Memory and Working Memory in Rats[J]. Chinese Journal of Clinical Psychology, 2007, 15(1): 88-91 | |
| Authors: | YANG Xin-hua ZHOU ping LI Yong-hui |
| Affiliation: | Mental Health Education Center, Hunan Agriculture University, Changsha 410128, China |
| Abstract: | Objective: To develop a animal model of Pb-induced cognitive deficits for helping to further study of the underlying neural mechanisms after lead intoxication.Methods: An experiment was designed to investigate the effects of chronic low level lead exposure(0.05% of lead acetate to pollute their drinking water for 28 days) on the spatial learning and memory of rats by Morris water maze.Results: The results revealed low level Pb exposure significantly impaired spatial reference memory and spatial working memory of rats,but did not affect their spatial learning.Conclusion: The behavioral results revealed that lead intoxication does not affect the acquisition of a water maze task.However,there is a deficit in reference memory and working memory performance. |
| Keywords: | Lead Spatial learning Reference memory Working memory |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |