KHM-1, a novel plasmid-mediated metallo-beta-lactamase from a Citrobacter freundii clinical isolate |
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| Authors: | Sekiguchi Jun-ichiro Morita Koji Kitao Tomoe Watanabe Noboru Okazaki Mitsuhiro Miyoshi-Akiyama Tohru Kanamori Masato Kirikae Teruo |
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| Affiliation: | Department of Infectious Diseases, Research Institute, International Medical Center of Japan, Shinjuku, Tokyo, Japan. |
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| Abstract: | ![]()
A novel gene, blaKHM-1, encoding a metallo-β-lactamase, KHM-1, was cloned from a clinical isolate of Citrobacter freundii resistant to most β-lactam antibiotics. Escherichia coli expressing blaKHM-1 was resistant to all broad-spectrum β-lactams except for monobactams and showed reduced susceptibility to carbapenems. Recombinant KHM-1 exhibited EDTA-inhibitable hydrolytic activity against most β-lactams, with an overall preference for cephalosporins. |
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