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| 亚硝酸钠和N—甲基苄胺的遗传毒性研究 | |
| 引用本文： | 洪振丰 王郑选. 亚硝酸钠和N—甲基苄胺的遗传毒性研究[J]. 癌变．畸变．突变, 1999, 11(5): 227-229 |
| 作者姓名： | 洪振丰 王郑选 |
| 作者单位： | 福建中医学院生物学教研室!福州350003 |
| 摘 要： | 作者研究观察了亚硝酸钠和Ｎ－甲基苄胺的遗传毒性作用。结果表明，亚硝酸钠和Ｎ－甲基苄胺不产生包性遗传毒性，但具有中长期生。长期接触可诱发大鼠胃窦及食道上皮的增生性病变，使胸腺指数降低，骨髓细胞ＭＮ‰升高。 |
| 关 键 词： | 亚硝酸钠 N－甲基苄胺 遗传毒性 |
THE STUDY ON GENOTOXICITY OF SODIUM NITRITE AND N METHYLBENZYLAMINE |
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| Hong Zhenfeng,Wang Zhenxian,Gao Bizhen,Xi Biyi,Chen Ling Fujian College of Traditional Chinese Medicine,Fuzhou. THE STUDY ON GENOTOXICITY OF SODIUM NITRITE AND N METHYLBENZYLAMINE[J]. Carcinogenesis,Teratogenesis and Mutagenesis, 1999, 11(5): 227-229 | |
| Authors: | Hong Zhenfeng Wang Zhenxian Gao Bizhen Xi Biyi Chen Ling Fujian College of Traditional Chinese Medicine Fuzhou |
| Abstract: | The genotoxicity of sodium nitrite and N methylbenzylamine were detected. The results showed that sodium nitrite and N methybenzylamine did not induce acute genotoxicity(P>0.5),but had a middle and long term genotoxicity. Exposed for long term, the gastric antrum and exophagus in the rats showed different levels hyperplastic change; and the per mil rate of micronuclei of marrow cells increased; the thymus gland indexes lowered. |
| Keywords: | Sodium nitrite N methylbenzylamine genotoxicity |
| 本文献已被 CNKI 维普 等数据库收录！ | |